Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 124925..125189 | Replicon | plasmid pS045-CMY-42 |
| Accession | NZ_CP076315 | ||
| Organism | Escherichia coli strain Survcare045 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Z417 |
| Locus tag | KNN08_RS01385 | Protein ID | WP_001387489.1 |
| Coordinates | 125037..125189 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 124925..124985 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KNN08_RS25155 (121035) | 121035..121193 | + | 159 | Protein_142 | ash family protein | - |
| KNN08_RS01360 (121231) | 121231..121518 | + | 288 | WP_000074855.1 | conjugal transfer protein TraA | - |
| KNN08_RS01365 (121960) | 121960..122268 | + | 309 | WP_039023235.1 | transcription termination/antitermination NusG family protein | - |
| KNN08_RS01375 (123032) | 123032..124189 | - | 1158 | Protein_146 | IS1380-like element ISEcp1 family transposase | - |
| KNN08_RS01380 (124342) | 124342..124716 | - | 375 | WP_223349261.1 | hypothetical protein | - |
| - (124925) | 124925..124985 | - | 61 | NuclAT_2 | - | Antitoxin |
| - (124925) | 124925..124985 | - | 61 | NuclAT_2 | - | Antitoxin |
| - (124925) | 124925..124985 | - | 61 | NuclAT_2 | - | Antitoxin |
| - (124925) | 124925..124985 | - | 61 | NuclAT_2 | - | Antitoxin |
| KNN08_RS01385 (125037) | 125037..125189 | + | 153 | WP_001387489.1 | Hok/Gef family protein | Toxin |
| KNN08_RS01390 (125261) | 125261..125512 | - | 252 | WP_001291964.1 | hypothetical protein | - |
| KNN08_RS25365 (126013) | 126013..126108 | + | 96 | WP_000609148.1 | DinQ-like type I toxin DqlB | - |
| KNN08_RS01400 (126173) | 126173..126349 | - | 177 | WP_001054897.1 | hypothetical protein | - |
| KNN08_RS01405 (126741) | 126741..126950 | + | 210 | WP_000062603.1 | HEAT repeat domain-containing protein | - |
| KNN08_RS01410 (127022) | 127022..127684 | - | 663 | WP_000644796.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| KNN08_RS01415 (127755) | 127755..129509 | - | 1755 | Protein_154 | DotA/TraY family protein | - |
| KNN08_RS01420 (129508) | 129508..129624 | - | 117 | Protein_155 | IncI1-type conjugal transfer lipoprotein TraH | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCMY-42 | - | 1..167285 | 167285 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5761.10 Da Isoelectric Point: 8.7948
>T205485 WP_001387489.1 NZ_CP076315:125037-125189 [Escherichia coli]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T205485 NZ_CP101689:c3604450-3604244 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATTCCCGAACTGCATCTTAAGGGCGACTGGCTGGCCGAGGCGGGATTTGAGACCGGGACGAGCGTAACCGTGAAGATCTC
GGAGGGGTGTTTGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCTGGTGAAAAAGTCGA
TGAAGCATATTAAGGCGGGGGTAAATAATGTGGTGAACAGGGATTAA
ATTCCCGAACTGCATCTTAAGGGCGACTGGCTGGCCGAGGCGGGATTTGAGACCGGGACGAGCGTAACCGTGAAGATCTC
GGAGGGGTGTTTGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCTGGTGAAAAAGTCGA
TGAAGCATATTAAGGCGGGGGTAAATAATGTGGTGAACAGGGATTAA
Antitoxin
Download Length: 61 bp
>AT205485 NZ_CP076315:c124985-124925 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
