Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3802391..3803084 Replicon chromosome
Accession NZ_CP076305
Organism Escherichia coli strain Survcare253

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag KNN07_RS18520 Protein ID WP_000415585.1
Coordinates 3802788..3803084 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KNN07_RS18515 Protein ID WP_000650107.1
Coordinates 3802391..3802786 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KNN07_RS18505 (3798255) 3798255..3800513 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
KNN07_RS18510 (3800651) 3800651..3802258 - 1608 WP_001375094.1 ABC transporter substrate-binding protein -
KNN07_RS18515 (3802391) 3802391..3802786 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KNN07_RS18520 (3802788) 3802788..3803084 - 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
KNN07_RS18525 (3803289) 3803289..3803771 - 483 WP_000183505.1 GyrI-like domain-containing protein -
KNN07_RS18530 (3803824) 3803824..3804216 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KNN07_RS18535 (3804368) 3804368..3805028 + 661 Protein_3648 quorum sensing response regulator transcription factor QseB -
KNN07_RS18540 (3805025) 3805025..3806374 + 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
KNN07_RS18545 (3806420) 3806420..3806752 - 333 WP_000914690.1 DUF2645 family protein -
KNN07_RS25045 (3806759) 3806759..3807469 - 711 WP_000834030.1 hypothetical protein -
KNN07_RS25050 (3807472) 3807472..3807951 - 480 WP_000065332.1 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T205461 WP_000415585.1 NZ_CP076305:c3803084-3802788 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T205461 NZ_CP101666:c2478840-2478667 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT205461 WP_000650107.1 NZ_CP076305:c3802786-3802391 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT205461 NZ_CP101666:c2479164-2478868 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References