Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 35098..35352 | Replicon | plasmid p321-NDM5 |
| Accession | NZ_CP076302 | ||
| Organism | Escherichia coli strain Survcare321 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | A0A1D7QA06 |
| Locus tag | KNN06_RS24540 | Protein ID | WP_001367749.1 |
| Coordinates | 35098..35247 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 35291..35352 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KNN06_RS24500 (30457) | 30457..30872 | - | 416 | Protein_38 | IS1-like element IS1B family transposase | - |
| KNN06_RS24505 (31121) | 31121..31522 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| KNN06_RS24510 (31455) | 31455..31712 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| KNN06_RS24515 (31805) | 31805..32458 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| KNN06_RS24520 (32556) | 32556..32696 | - | 141 | WP_001333237.1 | hypothetical protein | - |
| KNN06_RS24525 (33397) | 33397..34254 | - | 858 | WP_029702152.1 | incFII family plasmid replication initiator RepA | - |
| KNN06_RS24530 (34247) | 34247..34321 | - | 75 | WP_001365705.1 | RepA leader peptide Tap | - |
| KNN06_RS24535 (34557) | 34557..34814 | - | 258 | WP_000083833.1 | replication regulatory protein RepA | - |
| KNN06_RS24540 (35098) | 35098..35247 | - | 150 | WP_001367749.1 | Hok/Gef family protein | Toxin |
| - (35291) | 35291..35352 | + | 62 | NuclAT_0 | - | Antitoxin |
| - (35291) | 35291..35352 | + | 62 | NuclAT_0 | - | Antitoxin |
| - (35291) | 35291..35352 | + | 62 | NuclAT_0 | - | Antitoxin |
| - (35291) | 35291..35352 | + | 62 | NuclAT_0 | - | Antitoxin |
| KNN06_RS26120 (35491) | 35491..35919 | - | 429 | WP_029702151.1 | hypothetical protein | - |
| KNN06_RS24550 (36132) | 36132..36701 | - | 570 | WP_029702150.1 | DUF2726 domain-containing protein | - |
| KNN06_RS24555 (36853) | 36853..37479 | - | 627 | WP_029702149.1 | NYN domain-containing protein | - |
| KNN06_RS24560 (37891) | 37891..38100 | - | 210 | WP_039023209.1 | hypothetical protein | - |
| KNN06_RS24565 (38231) | 38231..38791 | - | 561 | WP_001567328.1 | fertility inhibition protein FinO | - |
| KNN06_RS24570 (38846) | 38846..39592 | - | 747 | WP_052273601.1 | conjugal transfer pilus acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaTEM-1B / mph(A) / blaNDM-5 / sul1 / qacE / aadA2 / dfrA12 / qepA4 / tet(B) | - | 1..127528 | 127528 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5528.64 Da Isoelectric Point: 8.7678
>T205436 WP_001367749.1 NZ_CP076302:c35247-35098 [Escherichia coli]
MTKYALIGVLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGVLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T205436 NZ_CP101648:4508811-4509227 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTCGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCGATTGGATCAAACGATGCTGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTCGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCGATTGGATCAAACGATGCTGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA
Antitoxin
Download Length: 62 bp
>AT205436 NZ_CP076302:35291-35352 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
