Detailed information of TA system TA205373

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1410040..1410411
• Replicon: chromosome
• Accession: NZ_CP076285
• Organism: Escherichia coli strain 41

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: -
• Locus tag: A7A12_RS06810
• Protein ID: WP_086563740.1
• Coordinates: 1410253..1410411 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1410040..1410218 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7A12_RS06785 (1405995)	1405995..1407368	+	1374	WP_000123739.1	ATP-dependent RNA helicase DbpA	-
A7A12_RS06790 (1407497)	1407497..1408432	-	936	WP_001157377.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
A7A12_RS06795 (1408484)	1408484..1409719	-	1236	WP_086563745.1	site-specific integrase	-
A7A12_RS06800 (1409721)	1409721..1409936	-	216	WP_086563743.1	excisionase XisR	-
- (1410040)	1410040..1410218	+	179	NuclAT_0	-	Antitoxin
- (1410040)	1410040..1410218	+	179	NuclAT_0	-	Antitoxin
- (1410040)	1410040..1410218	+	179	NuclAT_0	-	Antitoxin
- (1410040)	1410040..1410218	+	179	NuclAT_0	-	Antitoxin
A7A12_RS06805 (1410036)	1410036..1410224	-	189	WP_001595656.1	DUF1187 family protein	-
A7A12_RS06810 (1410253)	1410253..1410411	-	159	WP_086563740.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
A7A12_RS06815 (1410468)	1410468..1411277	-	810	WP_000166313.1	recombination protein RecT	-
A7A12_RS06820 (1411270)	1411270..1413870	-	2601	WP_001595659.1	exodeoxyribonuclease VIII	-
A7A12_RS06825 (1413972)	1413972..1414248	-	277	Protein_1331	hypothetical protein	-
A7A12_RS06830 (1414323)	1414323..1414493	-	171	WP_001516462.1	YdaE family protein	-
A7A12_RS06835 (1414493)	1414493..1414714	-	222	WP_000560211.1	killing protein KilR	-
A7A12_RS06840 (1415125)	1415125..1415277	-	153	WP_001169150.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1408484..1422987	14503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-52)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5811.62 Da
• Isoelectric Point: 8.6397

>T205373 WP_086563740.1 NZ_CP076285:c1410411-1410253 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNK

Nucleotide

• Length: 159 bp

>T205373 NZ_CP101595:c3729680-3729360 [Cronobacter dublinensis]
ATGCAAATCTCAACTGTACCGGCCACGTTGCCGGTTTCGTCACGCCTGTCACCTGTGCAGGTCTGGCAGCAACTTTTAAC
GTATCTACTGGAGCAGCATTACGGCCTGACACTCAACGACACGCCATTCCATGAGGACGCGGCCATTCAGGAACATATCG
AAGCGGGAATAACACTGGCTGATGCGGTGAATTTCCTAGTGGAACGTTATGAGCTGGTGCGTACTGACCGCAAAGGGTTT
ACATGGCAGGAGCAGACACCGTTCCTGACCGCTACCGATATTCTCAGAGCAAGGCGAGCTACCGGATTAATGAATACGTA
A

Antitoxin

Nucleotide

• Length: 179 bp

>AT205373 NZ_CP076285:1410040-1410218 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTAGTTAGTTTATATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTAGCGGTAATTTT

Structures

Antitoxin