Detailed information of TA system TA205371

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 1272938..1273158
• Replicon: chromosome
• Accession: NZ_CP076285
• Organism: Escherichia coli strain 41

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1PGT3
• Locus tag: A7A12_RS06105
• Protein ID: WP_000170954.1
• Coordinates: 1272938..1273045 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	1273092..1273158 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7A12_RS06080	1268782..1269864	+	1083	WP_000804726.1	peptide chain release factor 1	-
A7A12_RS06085	1269864..1270697	+	834	WP_000456471.1	peptide chain release factor N(5)-glutamine methyltransferase	-
A7A12_RS06090	1270694..1271086	+	393	WP_000200392.1	invasion regulator SirB2	-
A7A12_RS06095	1271090..1271899	+	810	WP_001257044.1	invasion regulator SirB1	-
A7A12_RS06100	1271935..1272789	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
A7A12_RS06105	1272938..1273045	-	108	WP_000170954.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	1273092..1273158	+	67	-	-	Antitoxin
A7A12_RS06110	1273450..1274550	-	1101	WP_001295620.1	sodium-potassium/proton antiporter ChaA	-
A7A12_RS06115	1274820..1275050	+	231	WP_001146442.1	putative cation transport regulator ChaB	-
A7A12_RS06120	1275208..1275903	+	696	WP_001295621.1	glutathione-specific gamma-glutamylcyclotransferase	-
A7A12_RS06125	1275947..1276300	-	354	WP_001169671.1	DsrE/F sulfur relay family protein YchN	-
A7A12_RS06130	1276485..1277879	+	1395	WP_000086213.1	inverse autotransporter invasin YchO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3983.80 Da
• Isoelectric Point: 11.4779

>T205371 WP_000170954.1 NZ_CP076285:c1273045-1272938 [Escherichia coli]
MTLAQFAMIFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T205371 NZ_CP101595:c2951672-2951310 [Cronobacter dublinensis]
ATGACATGGACGGTGATTTTTACCCCTCGTTTTTATGAGTGGTATCAACAACAGCCCGAAGGATTGCAGGATCGTATCGC
CGCGCTGTTATGGAATTTACGCCACAGCGGCCCGTTGGTTGGGCGTCCGCTGGTGGATACGATAAAAGGCTCGCAGATCC
CCAATCTCAAAGAGCTGCGCGTTCAGTATGGCGGTTCGCCGTGGCGGGTGTTTTTTGCCTTCGACCCAACCCGTCAGGCT
GTGGTGCTGTGTGCAGGCAACAAGCGCGGTCACAAAGACTTTTATAAAACCCTAATCAGGCAGGCGGAGGACGCGTTCTT
CCTGCATCTGCAAATCATGGAGAGTAAAAATGAAAACGCTTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT205371 NZ_CP076285:1273092-1273158 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A7U9LPE9

Antitoxin