Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 67601..67855 | Replicon | plasmid p4422IncF |
| Accession | NZ_CP076283 | ||
| Organism | Escherichia coli strain 442/2 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | Q0H0B2 |
| Locus tag | A7A15_RS23955 | Protein ID | WP_001300273.1 |
| Coordinates | 67601..67750 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 67794..67855 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A15_RS23925 (63746) | 63746..63901 | + | 156 | Protein_73 | IS110 family transposase | - |
| A7A15_RS23930 (64297) | 64297..64548 | - | 252 | WP_001315600.1 | HTH domain-containing protein | - |
| A7A15_RS23935 (65898) | 65898..66755 | - | 858 | WP_000131011.1 | incFII family plasmid replication initiator RepA | - |
| A7A15_RS23940 (66748) | 66748..66822 | - | 75 | WP_001365705.1 | RepA leader peptide Tap | - |
| A7A15_RS23945 (66871) | 66871..66996 | + | 126 | WP_071590472.1 | replication protein RepA | - |
| A7A15_RS23950 (67069) | 67069..67317 | - | 249 | WP_000083838.1 | replication regulatory protein RepA | - |
| A7A15_RS23955 (67601) | 67601..67750 | - | 150 | WP_001300273.1 | Hok/Gef family protein | Toxin |
| - (67794) | 67794..67855 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (67794) | 67794..67855 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (67794) | 67794..67855 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (67794) | 67794..67855 | + | 62 | NuclAT_1 | - | Antitoxin |
| A7A15_RS23960 (68515) | 68515..68976 | - | 462 | WP_000760077.1 | thermonuclease family protein | - |
| A7A15_RS23965 (69719) | 69719..69922 | - | 204 | WP_001327131.1 | hypothetical protein | - |
| A7A15_RS23970 (70077) | 70077..70634 | - | 558 | WP_000139319.1 | fertility inhibition protein FinO | - |
| A7A15_RS23975 (70737) | 70737..71597 | - | 861 | WP_000704512.1 | alpha/beta hydrolase | - |
| A7A15_RS23980 (71656) | 71656..72402 | - | 747 | WP_000205749.1 | conjugal transfer pilus acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..77995 | 77995 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5554.72 Da Isoelectric Point: 8.7678
>T205365 WP_001300273.1 NZ_CP076283:c67750-67601 [Escherichia coli]
MTKYALIGVLAVCATVLCFLLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGVLAVCATVLCFLLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T205365 NZ_CP101592:c162558-161239 [Cronobacter dublinensis]
ATGCGCCGCACGCCGCGCCTCGCGCTCTGGATGAACGGTATCCCGGTCGGCTACTGGGATAAACACAACGGCGAAGACCG
GCTGACCTATTTGCCGGAATGGACGAGCGATCCGCAGGGCAGGCCGCTGTCGCTGTCGCTGCCGTTCACGCCCGGCAATC
AGCCGTACCGCGGCGCGCGGGTGCGGGATTACTTCGATAATCTGCTGCCGGACAGCGAAGGCATCCGGCGGCGTCTTGCG
ACGCGCTACCGTGCGCAGAGCCTGGCGCCGTTCGATCTGCTGGCGGAGCTCGGGCGCGACTGCGTCGGGGCTATCCAGTT
GCTGCCCGACGGCGAGACGCCGGAAGGGCTGTTTACGATCCGCGCGCGACCGCTCTCCACAGTGGATATTGCCGCGATGC
TGCGCCACACCGCCGCGCCGTTTGCGGGCCAGCACGGCAGCGACGAGGAACTGCGGCTCTCCATTGCGGGCGCGCAGGAG
AAGACCGCGCTGCTGTGGCACGACGGCCAGTGGTGTCTGCCGGAGGGCAACACGCCCACCACGCATATTTTCAAACTGCC
GCTGGGGCTGGTGGGAAATATGCAGGCGGATATGCGCACCTCGATTGAAAATGAATGGCTCTGCTCGGTGCTGCTGGAGG
CCTACGGCATTCCGGTCGCGCGCACGCAGATGGCGCAGTTCGGGGATCAGAAAGCCTTAATCGTCGAGCGCTTCGACCGG
CGGCTGTCGGGCGATAAACAGTGGTGGCTGCGCCTGCCGCAGGAGGATATGTGTCAGGCGCTGGGCGTCTCGCCGCTGCG
TAAATATCAGGCCGACGGCGGGCCGGGCATCGGCGATATCATGACCATTCTGAGCCGCTCTGAACACGCGCAGGCCGACC
GCGCGCACTTTTTCCGTGCCCAGATTATCTTCTGGATCCTCGCGGCCACCGATGGCCACGCCAAAAACTTCAGCATCGCC
CATCTGCCCGGCAACCGCTATCACCTGACGCCGCTCTACGACGTGCTCTCGGCCTGGCCGGTTATCGGCCCCGGCAATCA
CCAGATTGCCTGGCAGAAATGCAAGCTGGCGATGGCGGTACGCGGCAGCAGCAATTACTACCATCTGAGTCAGATCCGCC
GCCGCCACTGGCTGCGCCAGGGCGAGCTCGCCGGGCTGTCGCCTGCGCAGGTCACGGAGATGATTGACGAGCTTATCGCC
GCGACGCCTGCTGCTGTCGCCCGCGCGGCTGAGGCGCTCCCGGCGGGCTTTCCATCCGCGCTCGCCGGTCAGATCTTCGA
CGGTATGCGCCAGCAGTGCGCGCGCCTCGCAAGCGCCTGA
ATGCGCCGCACGCCGCGCCTCGCGCTCTGGATGAACGGTATCCCGGTCGGCTACTGGGATAAACACAACGGCGAAGACCG
GCTGACCTATTTGCCGGAATGGACGAGCGATCCGCAGGGCAGGCCGCTGTCGCTGTCGCTGCCGTTCACGCCCGGCAATC
AGCCGTACCGCGGCGCGCGGGTGCGGGATTACTTCGATAATCTGCTGCCGGACAGCGAAGGCATCCGGCGGCGTCTTGCG
ACGCGCTACCGTGCGCAGAGCCTGGCGCCGTTCGATCTGCTGGCGGAGCTCGGGCGCGACTGCGTCGGGGCTATCCAGTT
GCTGCCCGACGGCGAGACGCCGGAAGGGCTGTTTACGATCCGCGCGCGACCGCTCTCCACAGTGGATATTGCCGCGATGC
TGCGCCACACCGCCGCGCCGTTTGCGGGCCAGCACGGCAGCGACGAGGAACTGCGGCTCTCCATTGCGGGCGCGCAGGAG
AAGACCGCGCTGCTGTGGCACGACGGCCAGTGGTGTCTGCCGGAGGGCAACACGCCCACCACGCATATTTTCAAACTGCC
GCTGGGGCTGGTGGGAAATATGCAGGCGGATATGCGCACCTCGATTGAAAATGAATGGCTCTGCTCGGTGCTGCTGGAGG
CCTACGGCATTCCGGTCGCGCGCACGCAGATGGCGCAGTTCGGGGATCAGAAAGCCTTAATCGTCGAGCGCTTCGACCGG
CGGCTGTCGGGCGATAAACAGTGGTGGCTGCGCCTGCCGCAGGAGGATATGTGTCAGGCGCTGGGCGTCTCGCCGCTGCG
TAAATATCAGGCCGACGGCGGGCCGGGCATCGGCGATATCATGACCATTCTGAGCCGCTCTGAACACGCGCAGGCCGACC
GCGCGCACTTTTTCCGTGCCCAGATTATCTTCTGGATCCTCGCGGCCACCGATGGCCACGCCAAAAACTTCAGCATCGCC
CATCTGCCCGGCAACCGCTATCACCTGACGCCGCTCTACGACGTGCTCTCGGCCTGGCCGGTTATCGGCCCCGGCAATCA
CCAGATTGCCTGGCAGAAATGCAAGCTGGCGATGGCGGTACGCGGCAGCAGCAATTACTACCATCTGAGTCAGATCCGCC
GCCGCCACTGGCTGCGCCAGGGCGAGCTCGCCGGGCTGTCGCCTGCGCAGGTCACGGAGATGATTGACGAGCTTATCGCC
GCGACGCCTGCTGCTGTCGCCCGCGCGGCTGAGGCGCTCCCGGCGGGCTTTCCATCCGCGCTCGCCGGTCAGATCTTCGA
CGGTATGCGCCAGCAGTGCGCGCGCCTCGCAAGCGCCTGA
Antitoxin
Download Length: 62 bp
>AT205365 NZ_CP076283:67794-67855 [Escherichia coli]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
