Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
| Location | 4247208..4247810 | Replicon | chromosome |
| Accession | NZ_CP076282 | ||
| Organism | Escherichia coli strain 442/2 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U9XIS6 |
| Locus tag | A7A15_RS20740 | Protein ID | WP_000897305.1 |
| Coordinates | 4247208..4247519 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | A7A15_RS20745 | Protein ID | WP_000356397.1 |
| Coordinates | 4247520..4247810 (+) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A15_RS20710 (4242238) | 4242238..4243023 | + | 786 | WP_000059678.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| A7A15_RS20715 (4243122) | 4243122..4243721 | + | 600 | WP_001295269.1 | glucose-1-phosphatase | - |
| A7A15_RS20720 (4243715) | 4243715..4244587 | + | 873 | WP_000920762.1 | virulence factor BrkB family protein | - |
| A7A15_RS20725 (4244584) | 4244584..4245021 | + | 438 | WP_000560983.1 | D-aminoacyl-tRNA deacylase | - |
| A7A15_RS20730 (4245066) | 4245066..4246007 | + | 942 | WP_001297068.1 | fatty acid biosynthesis protein FabY | - |
| A7A15_RS20735 (4246071) | 4246071..4246979 | - | 909 | WP_001162704.1 | alpha/beta hydrolase | - |
| A7A15_RS20740 (4247208) | 4247208..4247519 | + | 312 | WP_000897305.1 | hypothetical protein | Toxin |
| A7A15_RS20745 (4247520) | 4247520..4247810 | + | 291 | WP_000356397.1 | NadS family protein | Antitoxin |
| A7A15_RS20750 (4248415) | 4248415..4248633 | + | 219 | WP_001295676.1 | CopG family transcriptional regulator | - |
| A7A15_RS20755 (4248852) | 4248852..4249094 | + | 243 | WP_001086388.1 | protein YiiF | - |
| A7A15_RS20760 (4249424) | 4249424..4250353 | - | 930 | WP_000027708.1 | formate dehydrogenase accessory protein FdhE | - |
| A7A15_RS20765 (4250350) | 4250350..4250985 | - | 636 | WP_000829013.1 | formate dehydrogenase cytochrome b556 subunit | - |
| A7A15_RS20770 (4250982) | 4250982..4251884 | - | 903 | WP_000331377.1 | formate dehydrogenase O subunit beta | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12190.19 Da Isoelectric Point: 9.7791
>T205357 WP_000897305.1 NZ_CP076282:4247208-4247519 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
Download Length: 312 bp
>T205357 NZ_CP101591:240673-241200 [Cronobacter dublinensis]
ATGACGCTTAAGCGAGGCGTTTTTTCTTACGCACCGGAACACGGCTGGAAGACGGCGTCGTTCGACTGCGGCTGTGACAC
ACTGAATGATTTTCTTCGCCAGCGCCTTGCAGTGCAGCAGCAGCGCAATGTTCTGCGTGCGTATGTCGTGTTAACCAACG
AGCCGGAGCCTGCGGTCGCTGGCTACTACACGCTGTCGGGCGCCTCTTTCGAGAGGTCGCTGTTTGGCGATCGGAAGCGG
CAGATCCCTTATGATAGCGCGCCATGCGTGTTACTGGGCAGGCTGGCGGTAGACAAAACACATGCGGGAAAGGGCATAGG
GTCGATGCTGGTGGCGGATGCCGCGAGACGCGTTTATGACGTCGCCCGTGCGGTAGGCGTCTATGCGATGTTTGTGGAAG
CGAAAGATGCGCACGCCGCGCAGTTTTATCAGCAGCTCGGATTCCTGCAAGCAGAAAGTACCGACGGGCGACAGCGCCTG
TTTTTTCCGATCAGAGCACTCGACGCGTTATTCACTACAACACCATAA
ATGACGCTTAAGCGAGGCGTTTTTTCTTACGCACCGGAACACGGCTGGAAGACGGCGTCGTTCGACTGCGGCTGTGACAC
ACTGAATGATTTTCTTCGCCAGCGCCTTGCAGTGCAGCAGCAGCGCAATGTTCTGCGTGCGTATGTCGTGTTAACCAACG
AGCCGGAGCCTGCGGTCGCTGGCTACTACACGCTGTCGGGCGCCTCTTTCGAGAGGTCGCTGTTTGGCGATCGGAAGCGG
CAGATCCCTTATGATAGCGCGCCATGCGTGTTACTGGGCAGGCTGGCGGTAGACAAAACACATGCGGGAAAGGGCATAGG
GTCGATGCTGGTGGCGGATGCCGCGAGACGCGTTTATGACGTCGCCCGTGCGGTAGGCGTCTATGCGATGTTTGTGGAAG
CGAAAGATGCGCACGCCGCGCAGTTTTATCAGCAGCTCGGATTCCTGCAAGCAGAAAGTACCGACGGGCGACAGCGCCTG
TTTTTTCCGATCAGAGCACTCGACGCGTTATTCACTACAACACCATAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10846.43 Da Isoelectric Point: 10.8907
>AT205357 WP_000356397.1 NZ_CP076282:4247520-4247810 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
Download Length: 291 bp
>AT205357 NZ_CP101591:240317-240676 [Cronobacter dublinensis]
ATGGAACCTTCAGCGCCTACCCTGCATGTACGGTTATTTACCGTACAACAAAACCGTTTTTTGTCAGGGGACTCTGTTAT
GCCTGCGCCGTCGAAAAAAGACCGTCTGGAGTGTCGTCTCTCCACGGAGGACAAAGCTGCTATTGAAGCGGCTGCCAGCC
TCTCAAACACCAGCGTCTCGCAATTTATTGTCGATGCCGCTCGCGCTCGCGCCCGAGTCTTGCTTGAAGAACATCACCGT
ATCCGGTTAACGGAGCAGGGCTGGCATGCCGTTATGGCGGCGCTGGATAACCCACCTGCGCCAAACGAGAGACTCAAGCG
TGCGTTTGAAAGCCTGGATAACGGTGAATTCTGGGAATGA
ATGGAACCTTCAGCGCCTACCCTGCATGTACGGTTATTTACCGTACAACAAAACCGTTTTTTGTCAGGGGACTCTGTTAT
GCCTGCGCCGTCGAAAAAAGACCGTCTGGAGTGTCGTCTCTCCACGGAGGACAAAGCTGCTATTGAAGCGGCTGCCAGCC
TCTCAAACACCAGCGTCTCGCAATTTATTGTCGATGCCGCTCGCGCTCGCGCCCGAGTCTTGCTTGAAGAACATCACCGT
ATCCGGTTAACGGAGCAGGGCTGGCATGCCGTTATGGCGGCGCTGGATAACCCACCTGCGCCAAACGAGAGACTCAAGCG
TGCGTTTGAAAGCCTGGATAACGGTGAATTCTGGGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|