Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 1493847..1494218 | Replicon | chromosome |
| Accession | NZ_CP076282 | ||
| Organism | Escherichia coli strain 442/2 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A7W3G0W6 |
| Locus tag | A7A15_RS07265 | Protein ID | WP_072130784.1 |
| Coordinates | 1494024..1494218 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 1493847..1494025 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A15_RS07240 (1489802) | 1489802..1491175 | + | 1374 | WP_000123745.1 | ATP-dependent RNA helicase DbpA | - |
| A7A15_RS07245 (1491304) | 1491304..1492239 | - | 936 | WP_001157407.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| A7A15_RS07250 (1492291) | 1492291..1493526 | - | 1236 | WP_072001411.1 | site-specific integrase | - |
| A7A15_RS07255 (1493528) | 1493528..1493743 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (1493847) | 1493847..1494025 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1493847) | 1493847..1494025 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1493847) | 1493847..1494025 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1493847) | 1493847..1494025 | + | 179 | NuclAT_0 | - | Antitoxin |
| A7A15_RS07260 (1493843) | 1493843..1494031 | - | 189 | WP_001302840.1 | DUF1187 family protein | - |
| A7A15_RS07265 (1494024) | 1494024..1494218 | - | 195 | WP_072130784.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| A7A15_RS07270 (1494275) | 1494275..1495108 | - | 834 | WP_000166322.1 | recombination protein RecT | - |
| A7A15_RS07275 (1495101) | 1495101..1497752 | - | 2652 | WP_059340389.1 | exodeoxyribonuclease VIII | - |
| A7A15_RS07280 (1497854) | 1497854..1498129 | - | 276 | WP_032218014.1 | hypothetical protein | - |
| A7A15_RS07285 (1498204) | 1498204..1498380 | - | 177 | WP_032218016.1 | YdaE family protein | - |
| A7A15_RS07290 (1498374) | 1498374..1498595 | - | 222 | WP_000560226.1 | killing protein KilR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1492291..1539560 | 47269 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7135.00 Da Isoelectric Point: 8.0115
>T205338 WP_072130784.1 NZ_CP076282:c1494218-1494024 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKDISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTENINGGVHV
MRYDDVKPCPFCGCPSVTVKDISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTENINGGVHV
Download Length: 195 bp
>T205338 NZ_CP101564:62541-62690 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 179 bp
>AT205338 NZ_CP076282:1493847-1494025 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
