Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 4481609..4482211 | Replicon | chromosome |
Accession | NZ_CP076279 | ||
Organism | Escherichia coli strain SA53-3 |
Toxin (Protein)
Gene name | higB | Uniprot ID | U9XIS6 |
Locus tag | A7A19_RS22270 | Protein ID | WP_000897305.1 |
Coordinates | 4481609..4481920 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | A7A19_RS22275 | Protein ID | WP_000356397.1 |
Coordinates | 4481921..4482211 (+) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A7A19_RS22240 (4476639) | 4476639..4477424 | + | 786 | WP_000059678.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
A7A19_RS22245 (4477523) | 4477523..4478122 | + | 600 | WP_001295269.1 | glucose-1-phosphatase | - |
A7A19_RS22250 (4478116) | 4478116..4478988 | + | 873 | WP_000920762.1 | virulence factor BrkB family protein | - |
A7A19_RS22255 (4478985) | 4478985..4479422 | + | 438 | WP_000560983.1 | D-aminoacyl-tRNA deacylase | - |
A7A19_RS22260 (4479467) | 4479467..4480408 | + | 942 | WP_001343389.1 | fatty acid biosynthesis protein FabY | - |
A7A19_RS22265 (4480472) | 4480472..4481380 | - | 909 | WP_001162704.1 | alpha/beta hydrolase | - |
A7A19_RS22270 (4481609) | 4481609..4481920 | + | 312 | WP_000897305.1 | hypothetical protein | Toxin |
A7A19_RS22275 (4481921) | 4481921..4482211 | + | 291 | WP_000356397.1 | NadS family protein | Antitoxin |
A7A19_RS22280 (4482797) | 4482797..4483015 | + | 219 | WP_001295676.1 | CopG family transcriptional regulator | - |
A7A19_RS22285 (4483234) | 4483234..4483476 | + | 243 | WP_001087409.1 | protein YiiF | - |
A7A19_RS22290 (4483805) | 4483805..4484734 | - | 930 | WP_000027708.1 | formate dehydrogenase accessory protein FdhE | - |
A7A19_RS22295 (4484731) | 4484731..4485366 | - | 636 | WP_000829013.1 | formate dehydrogenase cytochrome b556 subunit | - |
A7A19_RS22300 (4485363) | 4485363..4486265 | - | 903 | WP_000331377.1 | formate dehydrogenase O subunit beta | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12190.19 Da Isoelectric Point: 9.7791
>T205323 WP_000897305.1 NZ_CP076279:4481609-4481920 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
Download Length: 312 bp
>T205323 NZ_CP101556:c2648-2496 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10846.43 Da Isoelectric Point: 10.8907
>AT205323 WP_000356397.1 NZ_CP076279:4481921-4482211 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
Download Length: 291 bp
>AT205323 NZ_CP101556:2700-2760 [Klebsiella pneumoniae subsp. pneumoniae]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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