Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 1559231..1559602 | Replicon | chromosome |
| Accession | NZ_CP076279 | ||
| Organism | Escherichia coli strain SA53-3 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A839BBC2 |
| Locus tag | A7A19_RS07765 | Protein ID | WP_021500490.1 |
| Coordinates | 1559408..1559602 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 1559231..1559409 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A19_RS07735 (1554983) | 1554983..1555156 | + | 174 | WP_001296046.1 | protein YnaL | - |
| A7A19_RS07740 (1555186) | 1555186..1556559 | + | 1374 | WP_000123738.1 | ATP-dependent RNA helicase DbpA | - |
| A7A19_RS07745 (1556688) | 1556688..1557623 | - | 936 | WP_001157377.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| A7A19_RS07750 (1557675) | 1557675..1558910 | - | 1236 | WP_072017917.1 | site-specific integrase | - |
| A7A19_RS07755 (1558912) | 1558912..1559127 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (1559231) | 1559231..1559409 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1559231) | 1559231..1559409 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1559231) | 1559231..1559409 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1559231) | 1559231..1559409 | + | 179 | NuclAT_0 | - | Antitoxin |
| A7A19_RS07760 (1559227) | 1559227..1559415 | - | 189 | WP_001383994.1 | DUF1187 family protein | - |
| A7A19_RS07765 (1559408) | 1559408..1559602 | - | 195 | WP_021500490.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| A7A19_RS07770 (1559666) | 1559666..1560754 | - | 1089 | WP_021529594.1 | RecT family recombinase | - |
| A7A19_RS07775 (1560769) | 1560769..1563915 | - | 3147 | WP_257122798.1 | exodeoxyribonuclease VIII | - |
| A7A19_RS07780 (1564017) | 1564017..1564292 | - | 276 | WP_000632298.1 | hypothetical protein | - |
| A7A19_RS07785 (1564367) | 1564367..1564537 | - | 171 | WP_087907244.1 | YdaE family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1557675..1608499 | 50824 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7046.98 Da Isoelectric Point: 9.2886
>T205302 WP_021500490.1 NZ_CP076279:c1559602-1559408 [Escherichia coli]
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
>T205302 NZ_CP101546:3975513-3975731 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 179 bp
>AT205302 NZ_CP076279:1559231-1559409 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCCGATTTGGTTAACTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCCGATTTGGTTAACTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
