Detailed information of TA system TA205262

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralR-sib/-
• Location: 1526758..1527129
• Replicon: chromosome
• Accession: NZ_CP076276
• Organism: Escherichia coli strain SA31-1

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: -
• Locus tag: A7A21_RS07520
• Protein ID: WP_089553771.1
• Coordinates: 1526935..1527129 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	sib
Locus tag	-
Coordinates	1526758..1526936 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7A21_RS07490 (1522510)	1522510..1522683	+	174	WP_001296046.1	protein YnaL	-
A7A21_RS07495 (1522713)	1522713..1524086	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
A7A21_RS07500 (1524215)	1524215..1525150	-	936	WP_001157377.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
A7A21_RS07505 (1525202)	1525202..1526437	-	1236	WP_072147472.1	site-specific integrase	-
A7A21_RS07510 (1526439)	1526439..1526654	-	216	WP_057697088.1	excisionase XisR	-
- (1526758)	1526758..1526936	+	179	NuclAT_1	-	Antitoxin
- (1526758)	1526758..1526936	+	179	NuclAT_1	-	Antitoxin
- (1526758)	1526758..1526936	+	179	NuclAT_1	-	Antitoxin
- (1526758)	1526758..1526936	+	179	NuclAT_1	-	Antitoxin
A7A21_RS07515 (1526754)	1526754..1526942	-	189	WP_089619309.1	DUF1187 family protein	-
A7A21_RS07520 (1526935)	1526935..1527129	-	195	WP_089553771.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
A7A21_RS07525 (1527186)	1527186..1528016	-	831	WP_089553749.1	recombination protein RecT	-
A7A21_RS07530 (1528009)	1528009..1530660	-	2652	WP_257114914.1	exodeoxyribonuclease VIII	-
A7A21_RS07535 (1530762)	1530762..1531037	-	276	WP_032218014.1	hypothetical protein	-
A7A21_RS07540 (1531112)	1531112..1531288	-	177	WP_032218016.1	YdaE family protein	-
A7A21_RS07545 (1531282)	1531282..1531503	-	222	WP_000560226.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1525202..1573103	47901

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 6973.89 Da
• Isoelectric Point: 8.9538

>T205262 WP_089553771.1 NZ_CP076276:c1527129-1526935 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKGISGYYRVKCNGCESRSGYGGSEKAALERWNKRTIGNNNGGVHV

Nucleotide

• Length: 195 bp

>T205262 NZ_CP101533:c2752773-2751451 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Nucleotide

• Length: 179 bp

>AT205262 NZ_CP076276:1526758-1526936 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTATAATTCATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTTCCTGA
GAGCATTTTTTCACATTCTGATTTGGTTAGTTTTGTTTTTGAGTATCTTGTCCAGTTGGTAGGCGAACCGCCTTCCTTTT
CAATAGTGGCAGTAATTTT

Structures

Antitoxin