Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 45782..46036 | Replicon | plasmid pP393F10IncF |
| Accession | NZ_CP076275 | ||
| Organism | Escherichia coli strain P393-F10 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | Q0H0B2 |
| Locus tag | A7A10_RS25420 | Protein ID | WP_001300273.1 |
| Coordinates | 45782..45931 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 45975..46036 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A10_RS25375 (41619) | 41619..41876 | - | 258 | Protein_32 | cloacin immunity family protein | - |
| A7A10_RS25380 (41886) | 41886..42041 | - | 156 | Protein_33 | colicin E3/pyocin S6 family cytotoxin | - |
| A7A10_RS25385 (42267) | 42267..42515 | - | 249 | WP_257115041.1 | hypothetical protein | - |
| A7A10_RS25390 (42607) | 42607..42882 | - | 276 | WP_000421257.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| A7A10_RS25395 (42882) | 42882..43166 | - | 285 | WP_001178089.1 | ribbon-helix-helix domain-containing protein | - |
| A7A10_RS25400 (44079) | 44079..44936 | - | 858 | WP_000131011.1 | incFII family plasmid replication initiator RepA | - |
| A7A10_RS25405 (44929) | 44929..45003 | - | 75 | WP_001365705.1 | RepA leader peptide Tap | - |
| A7A10_RS25410 (45052) | 45052..45177 | + | 126 | WP_001436741.1 | hypothetical protein | - |
| A7A10_RS25415 (45250) | 45250..45498 | - | 249 | WP_257185968.1 | replication regulatory protein RepA | - |
| A7A10_RS25420 (45782) | 45782..45931 | - | 150 | WP_001300273.1 | Hok/Gef family protein | Toxin |
| - (45975) | 45975..46036 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (45975) | 45975..46036 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (45975) | 45975..46036 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (45975) | 45975..46036 | + | 62 | NuclAT_1 | - | Antitoxin |
| A7A10_RS25425 (46211) | 46211..46345 | - | 135 | WP_001058542.1 | hypothetical protein | - |
| A7A10_RS25430 (46696) | 46696..47156 | - | 461 | Protein_43 | thermonuclease family protein | - |
| A7A10_RS25435 (47186) | 47186..48799 | - | 1614 | WP_000080195.1 | IS66-like element ISEc23 family transposase | - |
| A7A10_RS25440 (48830) | 48830..49180 | - | 351 | WP_000624722.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| A7A10_RS25445 (49177) | 49177..49602 | - | 426 | WP_257115045.1 | transposase | - |
| A7A10_RS25450 (50442) | 50442..50645 | - | 204 | WP_001327131.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..153041 | 153041 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5554.72 Da Isoelectric Point: 8.7678
>T205251 WP_001300273.1 NZ_CP076275:c45931-45782 [Escherichia coli]
MTKYALIGVLAVCATVLCFLLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGVLAVCATVLCFLLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T205251 NZ_CP101525:2329913-2330296 [Burkholderia arboris]
ATGAGTGTCTTGGTCGACACGTCCGTGTGGGTCGAGCATTTCCGGCGGCCACTCCCGGCACTTATCCAACTTCTGCGCGT
CGATAGCATCCTTACACATCCGCTGGTGATACTTGAGCTCACGTGCGGGACACCACCCGAACCGCGGGCACGAACGCTGG
GAGATCTCGCGTTATTGCGCCAAACGCGCCTCGCGACGCCAGGCGAAGTAGCGGACTGGATCGAGCGGGAACGGCTGTAT
GGGCGCGGATGCGGTGCCGTGGATTGCACGCTGCTTGCATCGGTGCTGTTGACCCCGAGCACCCGGCTCTGGACGCGTGA
TCGGCGGCTCGCGCAACTGGCAGAGCGATTCGGGGCCCAATACGTACCGCCTGACCTGCATTGA
ATGAGTGTCTTGGTCGACACGTCCGTGTGGGTCGAGCATTTCCGGCGGCCACTCCCGGCACTTATCCAACTTCTGCGCGT
CGATAGCATCCTTACACATCCGCTGGTGATACTTGAGCTCACGTGCGGGACACCACCCGAACCGCGGGCACGAACGCTGG
GAGATCTCGCGTTATTGCGCCAAACGCGCCTCGCGACGCCAGGCGAAGTAGCGGACTGGATCGAGCGGGAACGGCTGTAT
GGGCGCGGATGCGGTGCCGTGGATTGCACGCTGCTTGCATCGGTGCTGTTGACCCCGAGCACCCGGCTCTGGACGCGTGA
TCGGCGGCTCGCGCAACTGGCAGAGCGATTCGGGGCCCAATACGTACCGCCTGACCTGCATTGA
Antitoxin
Download Length: 62 bp
>AT205251 NZ_CP076275:45975-46036 [Escherichia coli]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
