Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
| Location | 3633995..3634794 | Replicon | chromosome |
| Accession | NZ_CP076274 | ||
| Organism | Escherichia coli strain P393-F10 | ||
Toxin (Protein)
| Gene name | yhaV | Uniprot ID | F4VJD3 |
| Locus tag | A7A10_RS17980 | Protein ID | WP_000347266.1 |
| Coordinates | 3634330..3634794 (+) | Length | 155 a.a. |
Antitoxin (Protein)
| Gene name | prlF | Uniprot ID | S1EB98 |
| Locus tag | A7A10_RS17975 | Protein ID | WP_001307405.1 |
| Coordinates | 3633995..3634330 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A10_RS17960 (3629780) | 3629780..3630550 | - | 771 | WP_001058227.1 | 2-dehydro-3-deoxyglucarate aldolase | - |
| A7A10_RS17965 (3630566) | 3630566..3631900 | - | 1335 | WP_000599636.1 | galactarate/glucarate/glycerate transporter GarP | - |
| A7A10_RS17970 (3632275) | 3632275..3633846 | + | 1572 | WP_001273741.1 | galactarate dehydratase | - |
| A7A10_RS17975 (3633995) | 3633995..3634330 | + | 336 | WP_001307405.1 | type II toxin-antitoxin system antitoxin PrlF | Antitoxin |
| A7A10_RS17980 (3634330) | 3634330..3634794 | + | 465 | WP_000347266.1 | type II toxin-antitoxin system ribonuclease toxin YhaV | Toxin |
| A7A10_RS17985 (3634849) | 3634849..3635658 | - | 810 | WP_000072187.1 | aga operon transcriptional regulator AgaR | - |
| A7A10_RS17990 (3635907) | 3635907..3637187 | + | 1281 | WP_000681921.1 | tagatose-bisphosphate aldolase subunit KbaZ | - |
| A7A10_RS17995 (3637210) | 3637210..3637683 | + | 474 | WP_001295547.1 | PTS N-acetylgalactosamine transporter subunit IIB | - |
| A7A10_RS18000 (3637694) | 3637694..3638473 | + | 780 | WP_000406214.1 | PTS N-acetylgalactosamine transporter subunit IIC | - |
| A7A10_RS18005 (3638463) | 3638463..3639341 | + | 879 | WP_001315856.1 | PTS N-acetylgalactosamine transporter subunit IID | - |
| A7A10_RS18010 (3639359) | 3639359..3639793 | + | 435 | WP_000948824.1 | PTS galactosamine/N-acetylgalactosamine transporter subunit IIA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3621728..3634794 | 13066 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 17841.18 Da Isoelectric Point: 9.4947
>T205241 WP_000347266.1 NZ_CP076274:3634330-3634794 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH
Download Length: 465 bp
>T205241 NZ_CP101519:c160463-160077 [Ensifer adhaerens]
ATGGTCATCGATACCTCCGTCCTTGCCGCCATCGCCTTCAATGAGCCGGAAGCGGCGGCTTTCCGCGAGCGCATTGCAGA
CGACCCCGTCAGGCTCATCTCCGCCGCGACCGTCCTAGAGGCTGCCATGGTGATCGAAACTCGACTTGGGGAGGCCGCAG
GCGCCGATCTCGACCTCTGGCTCTACAAGGCAGAAGTCGAAATCGTCCCAGTTACAGCCGAACATTCCGATCGTGCGCGG
CGCGCCTGGCGTCGCTATGGTAAGGGACGTCATCCGGCCAGCCTCAACTACGGCGACTGCTTTTCCTATGCTCTTGCGGC
GCTTTCGGGAGAACCGCTCCTCTACAAGAGCAACGATTTTTCGCAAACCGACATCGAGGCGGCGTGA
ATGGTCATCGATACCTCCGTCCTTGCCGCCATCGCCTTCAATGAGCCGGAAGCGGCGGCTTTCCGCGAGCGCATTGCAGA
CGACCCCGTCAGGCTCATCTCCGCCGCGACCGTCCTAGAGGCTGCCATGGTGATCGAAACTCGACTTGGGGAGGCCGCAG
GCGCCGATCTCGACCTCTGGCTCTACAAGGCAGAAGTCGAAATCGTCCCAGTTACAGCCGAACATTCCGATCGTGCGCGG
CGCGCCTGGCGTCGCTATGGTAAGGGACGTCATCCGGCCAGCCTCAACTACGGCGACTGCTTTTCCTATGCTCTTGCGGC
GCTTTCGGGAGAACCGCTCCTCTACAAGAGCAACGATTTTTCGCAAACCGACATCGAGGCGGCGTGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12358.94 Da Isoelectric Point: 4.8616
>AT205241 WP_001307405.1 NZ_CP076274:3633995-3634330 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
Download Length: 336 bp
>AT205241 NZ_CP101519:c160717-160463 [Ensifer adhaerens]
ATGGCGCTGAGCATCAAAGACCACGACACTGAACAGCTGGCCCGCACCCTTGCCGAACGGACCGGCGAAAGCATCACACT
CGCAACCAAGCGCGCGCTCGAAGAGCGCCTGCGACGGCTTGGCTCTGACTTGCGCAAAGCCGCTCTCCTCGAGGACCTCG
AAGCGATCCAGCGACGCTGGAACGCTCGGCCCGTTCTCGACAGCCGCACAGCCGACGAAATTCTCGGCTACGACGAGAAC
GGACTGCCATCCTGA
ATGGCGCTGAGCATCAAAGACCACGACACTGAACAGCTGGCCCGCACCCTTGCCGAACGGACCGGCGAAAGCATCACACT
CGCAACCAAGCGCGCGCTCGAAGAGCGCCTGCGACGGCTTGGCTCTGACTTGCGCAAAGCCGCTCTCCTCGAGGACCTCG
AAGCGATCCAGCGACGCTGGAACGCTCGGCCCGTTCTCGACAGCCGCACAGCCGACGAAATTCTCGGCTACGACGAGAAC
GGACTGCCATCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A836NGD2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0XVC7 |