Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 1536480..1536851 | Replicon | chromosome |
| Accession | NZ_CP076274 | ||
| Organism | Escherichia coli strain P393-F10 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A839BBC2 |
| Locus tag | A7A10_RS07670 | Protein ID | WP_021500490.1 |
| Coordinates | 1536657..1536851 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 1536480..1536658 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A10_RS07645 (1532435) | 1532435..1533808 | + | 1374 | WP_000123745.1 | ATP-dependent RNA helicase DbpA | - |
| A7A10_RS07650 (1533937) | 1533937..1534872 | - | 936 | WP_001157377.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| A7A10_RS07655 (1534924) | 1534924..1536159 | - | 1236 | WP_257185856.1 | site-specific integrase | - |
| A7A10_RS07660 (1536161) | 1536161..1536376 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (1536480) | 1536480..1536658 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1536480) | 1536480..1536658 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1536480) | 1536480..1536658 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1536480) | 1536480..1536658 | + | 179 | NuclAT_0 | - | Antitoxin |
| A7A10_RS07665 (1536476) | 1536476..1536664 | - | 189 | WP_001383994.1 | DUF1187 family protein | - |
| A7A10_RS07670 (1536657) | 1536657..1536851 | - | 195 | WP_021500490.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| A7A10_RS07675 (1536915) | 1536915..1538003 | - | 1089 | WP_257185857.1 | RecT family recombinase | - |
| A7A10_RS07680 (1538018) | 1538018..1541164 | - | 3147 | WP_112015640.1 | exodeoxyribonuclease VIII | - |
| A7A10_RS07685 (1541266) | 1541266..1541541 | - | 276 | WP_000632298.1 | hypothetical protein | - |
| A7A10_RS07690 (1541616) | 1541616..1541786 | - | 171 | WP_087907244.1 | YdaE family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1534924..1582603 | 47679 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7046.98 Da Isoelectric Point: 9.2886
>T205222 WP_021500490.1 NZ_CP076274:c1536851-1536657 [Escherichia coli]
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
>T205222 NZ_CP101513:1982027-1982130 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 179 bp
>AT205222 NZ_CP076274:1536480-1536658 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTGGTTAACTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTGGTTAACTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
