Detailed information of TA system TA205189

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1557299..1557670
• Replicon: chromosome
• Accession: NZ_CP076272
• Organism: Escherichia coli strain E21845/O/A

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A7W3G0W6
• Locus tag: A7A11_RS07710
• Protein ID: WP_072130784.1
• Coordinates: 1557476..1557670 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1557299..1557477 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7A11_RS07680 (1553051)	1553051..1553224	+	174	WP_001296046.1	protein YnaL	-
A7A11_RS07685 (1553254)	1553254..1554627	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
A7A11_RS07690 (1554756)	1554756..1555691	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
A7A11_RS07695 (1555743)	1555743..1556978	-	1236	WP_072001411.1	site-specific integrase	-
A7A11_RS07700 (1556980)	1556980..1557195	-	216	WP_000079604.1	excisionase XisR	-
- (1557299)	1557299..1557477	+	179	NuclAT_0	-	Antitoxin
- (1557299)	1557299..1557477	+	179	NuclAT_0	-	Antitoxin
- (1557299)	1557299..1557477	+	179	NuclAT_0	-	Antitoxin
- (1557299)	1557299..1557477	+	179	NuclAT_0	-	Antitoxin
A7A11_RS07705 (1557295)	1557295..1557483	-	189	WP_001302840.1	DUF1187 family protein	-
A7A11_RS07710 (1557476)	1557476..1557670	-	195	WP_072130784.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
A7A11_RS07715 (1557727)	1557727..1558560	-	834	WP_000166322.1	recombination protein RecT	-
A7A11_RS07720 (1558553)	1558553..1561204	-	2652	WP_032218011.1	exodeoxyribonuclease VIII	-
A7A11_RS07725 (1561306)	1561306..1561581	-	276	WP_032218014.1	hypothetical protein	-
A7A11_RS07730 (1561656)	1561656..1561832	-	177	WP_032218016.1	YdaE family protein	-
A7A11_RS07735 (1561826)	1561826..1562047	-	222	WP_000560226.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1476745..1603031	126286

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7135.00 Da
• Isoelectric Point: 8.0115

>T205189 WP_072130784.1 NZ_CP076272:c1557670-1557476 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKDISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTENINGGVHV

Nucleotide

• Length: 195 bp

>T205189 NZ_CP101417:c1529322-1528906 [Xanthomonas hortorum]
GTGATCCTGCTCGATACCAATGTCATCTCCGAGCTTTGGCGGCCTCGGCCCAACCCGCAGGTCGTCGCCTGGATCGATGC
GCAGGCGGTTGAAACACTGTTCCTGTCGGTCGTGACGGTGGCTGAATTGCGTTTCGGCATTGCCGTGATGCCCGAGGGCC
GCAAGCGATCCACGTTGCATGCTCGGTTGGAAGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGACCTG
GACGCATCGCACGCATTTGCCACACTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACGGCAGCCGCGCAAGGCTTGGCCGTTGCCACTCGCGACACGGCACCCTTCGAGGCGATGGCGTTGGACGTCA
TTAACCCGTGGAGTTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT205189 NZ_CP076272:1557299-1557477 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7W3G0W6

Antitoxin