Detailed information of TA system TA205155

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1478151..1478522
• Replicon: chromosome
• Accession: NZ_CP076270
• Organism: Escherichia coli strain Ceylon31

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A7W3G0W6
• Locus tag: A7A14_RS07135
• Protein ID: WP_072130784.1
• Coordinates: 1478328..1478522 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1478151..1478329 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7A14_RS07110 (1474106)	1474106..1475479	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
A7A14_RS07115 (1475608)	1475608..1476543	-	936	WP_001157377.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
A7A14_RS07120 (1476595)	1476595..1477830	-	1236	WP_072147472.1	site-specific integrase	-
A7A14_RS07125 (1477832)	1477832..1478047	-	216	WP_057697088.1	excisionase XisR	-
- (1478151)	1478151..1478329	+	179	NuclAT_0	-	Antitoxin
- (1478151)	1478151..1478329	+	179	NuclAT_0	-	Antitoxin
- (1478151)	1478151..1478329	+	179	NuclAT_0	-	Antitoxin
- (1478151)	1478151..1478329	+	179	NuclAT_0	-	Antitoxin
A7A14_RS07130 (1478147)	1478147..1478335	-	189	WP_001302840.1	DUF1187 family protein	-
A7A14_RS07135 (1478328)	1478328..1478522	-	195	WP_072130784.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
A7A14_RS07140 (1478579)	1478579..1479413	-	835	Protein_1394	recombination protein RecT	-
A7A14_RS07145 (1479406)	1479406..1482057	-	2652	WP_069901049.1	exodeoxyribonuclease VIII	-
A7A14_RS07150 (1482159)	1482159..1482434	-	276	WP_032218014.1	hypothetical protein	-
A7A14_RS07155 (1482509)	1482509..1482685	-	177	WP_032218016.1	YdaE family protein	-
A7A14_RS07160 (1482679)	1482679..1482900	-	222	WP_000560226.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1476595..1523643	47048

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7135.00 Da
• Isoelectric Point: 8.0115

>T205155 WP_072130784.1 NZ_CP076270:c1478522-1478328 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKDISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTENINGGVHV

Nucleotide

• Length: 195 bp

>T205155 NZ_CP101388:3727922-3728197 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT205155 NZ_CP076270:1478151-1478329 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7W3G0W6

Antitoxin