Detailed information of TA system TA205126

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1476174..1476545
• Replicon: chromosome
• Accession: NZ_CP076268
• Organism: Escherichia coli strain D217-5

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A7W3G0W6
• Locus tag: A7A16_RS07140
• Protein ID: WP_072130784.1
• Coordinates: 1476351..1476545 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1476174..1476352 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7A16_RS07110 (1471926)	1471926..1472099	+	174	WP_001296046.1	protein YnaL	-
A7A16_RS07115 (1472129)	1472129..1473502	+	1374	WP_000123738.1	ATP-dependent RNA helicase DbpA	-
A7A16_RS07120 (1473631)	1473631..1474566	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
A7A16_RS07125 (1474618)	1474618..1475853	-	1236	WP_072001411.1	site-specific integrase	-
A7A16_RS07130 (1475855)	1475855..1476070	-	216	WP_000079604.1	excisionase XisR	-
- (1476174)	1476174..1476352	+	179	NuclAT_0	-	Antitoxin
- (1476174)	1476174..1476352	+	179	NuclAT_0	-	Antitoxin
- (1476174)	1476174..1476352	+	179	NuclAT_0	-	Antitoxin
- (1476174)	1476174..1476352	+	179	NuclAT_0	-	Antitoxin
A7A16_RS07135 (1476170)	1476170..1476358	-	189	WP_001302840.1	DUF1187 family protein	-
A7A16_RS07140 (1476351)	1476351..1476545	-	195	WP_072130784.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
A7A16_RS07145 (1476602)	1476602..1477435	-	834	WP_000166322.1	recombination protein RecT	-
A7A16_RS07150 (1477428)	1477428..1480079	-	2652	WP_112044433.1	exodeoxyribonuclease VIII	-
A7A16_RS07155 (1480181)	1480181..1480456	-	276	WP_032218014.1	hypothetical protein	-
A7A16_RS07160 (1480531)	1480531..1480707	-	177	WP_032218016.1	YdaE family protein	-
A7A16_RS07165 (1480701)	1480701..1480922	-	222	WP_000560226.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1474618..1523155	48537

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7135.00 Da
• Isoelectric Point: 8.0115

>T205126 WP_072130784.1 NZ_CP076268:c1476545-1476351 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKDISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTENINGGVHV

Nucleotide

• Length: 195 bp

>T205126 NZ_CP101382:c4400521-4400030 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT205126 NZ_CP076268:1476174-1476352 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7W3G0W6

Antitoxin