Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 91799..92225 | Replicon | plasmid pNADC1036IncF |
| Accession | NZ_CP076265 | ||
| Organism | Escherichia coli strain NADC1036 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | A7A17_RS24395 | Protein ID | WP_001372321.1 |
| Coordinates | 91799..91924 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 92001..92225 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A17_RS24350 (86848) | 86848..87075 | - | 228 | WP_001254386.1 | conjugal transfer relaxosome protein TraY | - |
| A7A17_RS24355 (87169) | 87169..87855 | - | 687 | WP_000332492.1 | PAS domain-containing protein | - |
| A7A17_RS24360 (88045) | 88045..88428 | - | 384 | WP_000124981.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| A7A17_RS24365 (88705) | 88705..89352 | + | 648 | WP_122985450.1 | transglycosylase SLT domain-containing protein | - |
| A7A17_RS24370 (89648) | 89648..90469 | - | 822 | Protein_96 | DUF945 domain-containing protein | - |
| A7A17_RS24375 (90590) | 90590..90877 | - | 288 | WP_000107542.1 | hypothetical protein | - |
| A7A17_RS24380 (90902) | 90902..91108 | - | 207 | WP_089649215.1 | single-stranded DNA-binding protein | - |
| A7A17_RS24385 (91178) | 91178..91348 | + | 171 | Protein_99 | hypothetical protein | - |
| A7A17_RS24390 (91349) | 91349..91579 | - | 231 | WP_071998556.1 | hypothetical protein | - |
| A7A17_RS24395 (91799) | 91799..91924 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| A7A17_RS24400 (91866) | 91866..92015 | - | 150 | Protein_102 | plasmid maintenance protein Mok | - |
| - (92001) | 92001..92225 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (92001) | 92001..92225 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (92001) | 92001..92225 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (92001) | 92001..92225 | - | 225 | NuclAT_0 | - | Antitoxin |
| A7A17_RS24405 (92037) | 92037..92225 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| A7A17_RS24410 (92194) | 92194..92956 | - | 763 | Protein_104 | plasmid SOS inhibition protein A | - |
| A7A17_RS24415 (92953) | 92953..93387 | - | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
| A7A17_RS24420 (93442) | 93442..95400 | - | 1959 | WP_257117817.1 | ParB/RepB/Spo0J family partition protein | - |
| A7A17_RS24425 (95466) | 95466..95699 | - | 234 | WP_000005990.1 | DUF905 family protein | - |
| A7A17_RS24430 (95762) | 95762..96301 | - | 540 | WP_000290838.1 | single-stranded DNA-binding protein | - |
| A7A17_RS24435 (96327) | 96327..96533 | - | 207 | WP_024190028.1 | hypothetical protein | - |
| A7A17_RS24440 (96774) | 96774..97010 | - | 237 | WP_077786645.1 | hypothetical protein | - |
| A7A17_RS24445 (96944) | 96944..97135 | - | 192 | WP_061336218.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | cdtC / cdtB / cdtA / cnf1 / hlyC / iutA / iucD / iucC / iucB / iucA / f17d-G / f17d-C / f17d-D / f17d-A | 1..145019 | 145019 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T205119 WP_001372321.1 NZ_CP076265:c91924-91799 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T205119 NZ_CP101382:c1077342-1076815 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA
Antitoxin
Download Length: 225 bp
>AT205119 NZ_CP076265:c92225-92001 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
