Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 1492495..1492866 | Replicon | chromosome |
| Accession | NZ_CP076264 | ||
| Organism | Escherichia coli strain NADC1036 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A4Z0JXD0 |
| Locus tag | A7A17_RS07290 | Protein ID | WP_001406909.1 |
| Coordinates | 1492672..1492866 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 1492495..1492673 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A17_RS07260 (1488247) | 1488247..1488420 | + | 174 | WP_001296046.1 | protein YnaL | - |
| A7A17_RS07265 (1488450) | 1488450..1489823 | + | 1374 | WP_000123745.1 | ATP-dependent RNA helicase DbpA | - |
| A7A17_RS07270 (1489952) | 1489952..1490887 | - | 936 | WP_001157377.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| A7A17_RS07275 (1490939) | 1490939..1492174 | - | 1236 | WP_000040843.1 | site-specific integrase | - |
| A7A17_RS07280 (1492176) | 1492176..1492391 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (1492495) | 1492495..1492673 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1492495) | 1492495..1492673 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1492495) | 1492495..1492673 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1492495) | 1492495..1492673 | + | 179 | NuclAT_0 | - | Antitoxin |
| A7A17_RS07285 (1492491) | 1492491..1492679 | - | 189 | WP_001406908.1 | DUF1187 family protein | - |
| A7A17_RS07290 (1492672) | 1492672..1492866 | - | 195 | WP_001406909.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| A7A17_RS07295 (1492929) | 1492929..1493981 | - | 1053 | WP_001406910.1 | RecT family recombinase | - |
| A7A17_RS07300 (1493993) | 1493993..1497115 | - | 3123 | WP_047662224.1 | exodeoxyribonuclease VIII | - |
| A7A17_RS07305 (1497217) | 1497217..1497492 | - | 276 | WP_032218014.1 | hypothetical protein | - |
| A7A17_RS07310 (1497567) | 1497567..1497743 | - | 177 | WP_032218016.1 | YdaE family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1490939..1542689 | 51750 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7001.00 Da Isoelectric Point: 9.6161
>T205090 WP_001406909.1 NZ_CP076264:c1492866-1492672 [Escherichia coli]
MRYEKVKPCPFCGCPSVTVKGISGYYRVKCNGCESRSGYGGSEKAALERWNKRTIGNNNGGVHV
MRYEKVKPCPFCGCPSVTVKGISGYYRVKCNGCESRSGYGGSEKAALERWNKRTIGNNNGGVHV
Download Length: 195 bp
>T205090 NZ_CP101376:3518740-3518958 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 179 bp
>AT205090 NZ_CP076264:1492495-1492673 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCACATTCTGATTTGGTTAGTTTTGTTTTTGAGTATCTTGTCCAGTTGGTAGGCGAACCGCCTTCCTTTT
CAATAGTGGCAGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCACATTCTGATTTGGTTAGTTTTGTTTTTGAGTATCTTGTCCAGTTGGTAGGCGAACCGCCTTCCTTTT
CAATAGTGGCAGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
