Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 45402..45666 | Replicon | plasmid pSA31IncI2 |
Accession | NZ_CP076261 | ||
Organism | Escherichia coli strain WY517-2 |
Toxin (Protein)
Gene name | pndA | Uniprot ID | U9Z417 |
Locus tag | A7A20_RS23955 | Protein ID | WP_001387489.1 |
Coordinates | 45402..45554 (-) | Length | 51 a.a. |
Antitoxin (RNA)
Gene name | pndB | ||
Locus tag | - | ||
Coordinates | 45604..45666 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A7A20_RS23920 (40519) | 40519..41732 | + | 1214 | WP_139371347.1 | IS3 family transposase | - |
A7A20_RS23925 (41774) | 41774..43036 | + | 1263 | Protein_45 | IncI1-type conjugal transfer membrane protein TraY | - |
A7A20_RS23930 (43112) | 43112..43726 | + | 615 | WP_000578648.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
A7A20_RS23935 (43824) | 43824..44033 | + | 210 | WP_001140543.1 | hemolysin expression modulator Hha | - |
A7A20_RS23940 (44242) | 44242..44418 | + | 177 | WP_001054904.1 | hypothetical protein | - |
A7A20_RS23945 (44483) | 44483..44779 | - | 297 | WP_001275298.1 | DinQ-like type I toxin DqlB | - |
A7A20_RS23950 (45079) | 45079..45330 | + | 252 | WP_001291965.1 | hypothetical protein | - |
A7A20_RS23955 (45402) | 45402..45554 | - | 153 | WP_001387489.1 | Hok/Gef family protein | Toxin |
- (45604) | 45604..45666 | + | 63 | NuclAT_0 | - | Antitoxin |
- (45604) | 45604..45666 | + | 63 | NuclAT_0 | - | Antitoxin |
- (45604) | 45604..45666 | + | 63 | NuclAT_0 | - | Antitoxin |
- (45604) | 45604..45666 | + | 63 | NuclAT_0 | - | Antitoxin |
- (45907) | 45907..45962 | + | 56 | NuclAT_1 | - | - |
- (45907) | 45907..45962 | + | 56 | NuclAT_1 | - | - |
- (45907) | 45907..45962 | + | 56 | NuclAT_1 | - | - |
- (45907) | 45907..45962 | + | 56 | NuclAT_1 | - | - |
A7A20_RS23960 (46156) | 46156..47109 | + | 954 | WP_021513958.1 | hypothetical protein | - |
A7A20_RS23965 (47327) | 47327..48535 | + | 1209 | WP_001383960.1 | IncI1-type conjugal transfer protein TrbA | - |
A7A20_RS23970 (48554) | 48554..49624 | + | 1071 | WP_257115099.1 | IncI1-type conjugal transfer protein TrbB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | basG | 1..115220 | 115220 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5761.10 Da Isoelectric Point: 8.7948
>T205051 WP_001387489.1 NZ_CP076261:c45554-45402 [Escherichia coli]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T205051 NZ_CP101373:365061-365336 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
Antitoxin
Download Length: 63 bp
>AT205051 NZ_CP076261:45604-45666 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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