Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 1505487..1505858 | Replicon | chromosome |
| Accession | NZ_CP076259 | ||
| Organism | Escherichia coli strain WY517-2 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A7W3G0W6 |
| Locus tag | A7A20_RS07280 | Protein ID | WP_072130784.1 |
| Coordinates | 1505664..1505858 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 1505487..1505665 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A20_RS07255 (1501442) | 1501442..1502815 | + | 1374 | WP_000123745.1 | ATP-dependent RNA helicase DbpA | - |
| A7A20_RS07260 (1502944) | 1502944..1503879 | - | 936 | WP_001157407.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| A7A20_RS07265 (1503931) | 1503931..1505166 | - | 1236 | WP_072001411.1 | site-specific integrase | - |
| A7A20_RS07270 (1505168) | 1505168..1505383 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (1505487) | 1505487..1505665 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1505487) | 1505487..1505665 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1505487) | 1505487..1505665 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1505487) | 1505487..1505665 | + | 179 | NuclAT_0 | - | Antitoxin |
| A7A20_RS07275 (1505483) | 1505483..1505671 | - | 189 | WP_001302840.1 | DUF1187 family protein | - |
| A7A20_RS07280 (1505664) | 1505664..1505858 | - | 195 | WP_072130784.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| A7A20_RS07285 (1505915) | 1505915..1506748 | - | 834 | WP_000166322.1 | recombination protein RecT | - |
| A7A20_RS07290 (1506741) | 1506741..1509392 | - | 2652 | WP_112044433.1 | exodeoxyribonuclease VIII | - |
| A7A20_RS07295 (1509494) | 1509494..1509769 | - | 276 | WP_032218014.1 | hypothetical protein | - |
| A7A20_RS07300 (1509844) | 1509844..1510020 | - | 177 | WP_032218016.1 | YdaE family protein | - |
| A7A20_RS07305 (1510014) | 1510014..1510235 | - | 222 | WP_000560226.1 | killing protein KilR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1503931..1555921 | 51990 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7135.00 Da Isoelectric Point: 8.0115
>T205024 WP_072130784.1 NZ_CP076259:c1505858-1505664 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKDISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTENINGGVHV
MRYDDVKPCPFCGCPSVTVKDISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTENINGGVHV
Download Length: 195 bp
>T205024 NZ_CP101369:3569789-3570007 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 179 bp
>AT205024 NZ_CP076259:1505487-1505665 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
