Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | symER/SymE(toxin) |
Location | 4727453..4727865 | Replicon | chromosome |
Accession | NZ_CP076245 | ||
Organism | Escherichia coli O157:H7 strain Balcarce_24.2 |
Toxin (Protein)
Gene name | symE | Uniprot ID | Q8FA88 |
Locus tag | JKN64_RS23725 | Protein ID | WP_000132630.1 |
Coordinates | 4727524..4727865 (+) | Length | 114 a.a. |
Antitoxin (RNA)
Gene name | symR | ||
Locus tag | - | ||
Coordinates | 4727453..4727529 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JKN64_RS23715 (4724080) | 4724080..4725549 | + | 1470 | WP_001302468.1 | type I restriction-modification system subunit M | - |
JKN64_RS23720 (4725549) | 4725549..4727303 | + | 1755 | WP_000110082.1 | restriction endonuclease subunit S | - |
- (4727453) | 4727453..4727529 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4727453) | 4727453..4727529 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4727453) | 4727453..4727529 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4727453) | 4727453..4727529 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4727453) | 4727453..4727529 | - | 77 | NuclAT_15 | - | Antitoxin |
- (4727453) | 4727453..4727529 | - | 77 | NuclAT_15 | - | Antitoxin |
- (4727453) | 4727453..4727529 | - | 77 | NuclAT_15 | - | Antitoxin |
- (4727453) | 4727453..4727529 | - | 77 | NuclAT_15 | - | Antitoxin |
JKN64_RS23725 (4727524) | 4727524..4727865 | + | 342 | WP_000132630.1 | endoribonuclease SymE | Toxin |
JKN64_RS23730 (4727912) | 4727912..4729075 | - | 1164 | WP_001304006.1 | DUF1524 domain-containing protein | - |
JKN64_RS23735 (4729123) | 4729123..4730004 | - | 882 | WP_001304007.1 | DUF262 domain-containing protein | - |
JKN64_RS23740 (4730147) | 4730147..4730299 | - | 153 | WP_001418365.1 | hypothetical protein | - |
JKN64_RS23745 (4730442) | 4730442..4731854 | + | 1413 | WP_000199295.1 | PLP-dependent aminotransferase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | espX6 | 4719652..4740879 | 21227 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12294.13 Da Isoelectric Point: 8.4982
>T204980 WP_000132630.1 NZ_CP076245:4727524-4727865 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
Download Length: 342 bp
>T204980 NZ_CP076245:4727524-4727865 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
Antitoxin
Download Length: 77 bp
>AT204980 NZ_CP076245:c4727529-4727453 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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