Detailed information of TA system TA020494

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1800946..1801539
• Replicon: chromosome
• Accession: NC_002937
• Organism: Desulfovibrio vulgaris str. Hildenborough

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q72BA7
• Locus tag: DVU_RS08220
• Protein ID: WP_010939017.1
• Coordinates: 1800946..1801224 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DVU_RS08225
• Protein ID: WP_010939018.1
• Coordinates: 1801234..1801539 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DVU_RS08185	1796428..1796781	-	354	WP_010939010.1	hypothetical protein	-
DVU_RS08190	1796778..1797332	-	555	WP_010939011.1	hypothetical protein	-
DVU_RS08195	1797329..1798933	-	1605	WP_010939012.1	hypothetical protein	-
DVU_RS08200	1798920..1799528	-	609	WP_010939013.1	hypothetical protein	-
DVU_RS08205	1799664..1799912	-	249	WP_010939014.1	hypothetical protein	-
DVU_RS08210	1799909..1800259	-	351	WP_010939015.1	hypothetical protein	-
DVU_RS08215	1800259..1800675	-	417	WP_010939016.1	hypothetical protein	-
DVU_RS08220	1800946..1801224	+	279	WP_010939017.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DVU_RS08225	1801234..1801539	+	306	WP_010939018.1	HigA family addiction module antidote protein	Antitoxin
DVU_RS08230	1802141..1805941	+	3801	WP_014524399.1	hypothetical protein	-
DVU_RS08235	1805962..1806105	+	144	WP_010939023.1	BrnT family toxin	-
DVU_RS08240	1806089..1806283	+	195	WP_010939024.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1770879..1822728	51849

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-65)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10558.00 Da
• Isoelectric Point: 7.8928

>T20494 WP_010939017.1 NC_002937:1800946-1801224 [Desulfovibrio vulgaris str. Hildenborough]
MIASFRCKETRSLFDGGTSRRFQAFSAVALRKLDMLDAAVSLDDLRIPPANRLEALKGDRQGQHSIRINDQWRVCFVWRD
GAPHDVEIVDYH

Nucleotide

• Length: 279 bp

>T20494 NC_002937:1800946-1801224 [Desulfovibrio vulgaris str. Hildenborough]
ATGATAGCGTCATTCCGCTGTAAGGAGACCCGCAGCCTTTTCGACGGCGGCACGAGCCGTCGCTTTCAGGCGTTCTCCGC
AGTGGCCCTGCGCAAGCTCGACATGCTCGATGCGGCGGTAAGCCTGGACGACCTGCGCATTCCCCCCGCGAACCGGCTCG
AAGCCCTCAAGGGCGACAGGCAAGGGCAACACAGCATCCGCATCAACGACCAGTGGCGTGTGTGCTTTGTCTGGCGCGAT
GGCGCACCGCATGACGTGGAAATCGTCGACTACCACTAG

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10893.47 Da
• Isoelectric Point: 9.2414

>AT20494 WP_010939018.1 NC_002937:1801234-1801539 [Desulfovibrio vulgaris str. Hildenborough]
MRIRTHPGEVLNEEFLKPLGVTAHALAVALGVPATRIADIVHQRRGVSADTAARLARFFGTSAAFWMNLQSAYDLSIVER
DKGADLSHIRPHASVGTSLSC

Nucleotide

• Length: 306 bp

>AT20494 NC_002937:1801234-1801539 [Desulfovibrio vulgaris str. Hildenborough]
ATGCGCATTCGCACCCACCCGGGCGAAGTCCTGAACGAAGAGTTCCTCAAGCCGCTTGGCGTCACCGCCCATGCTCTGGC
AGTGGCCCTTGGCGTACCGGCCACCCGCATCGCAGACATCGTGCACCAGCGGCGCGGCGTCTCTGCGGATACGGCAGCCC
GCCTCGCGCGCTTCTTCGGCACCAGTGCGGCATTCTGGATGAACCTTCAGTCGGCCTATGACCTTTCCATCGTCGAGCGC
GACAAGGGGGCCGACCTCTCGCACATCCGCCCGCACGCCAGCGTGGGCACTTCCCTCTCGTGCTGA

Structures

Toxin

• AlphaFold DB: Q72BA7