Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | symER/SymE(toxin) |
Location | 4751804..4752216 | Replicon | chromosome |
Accession | NZ_CP076241 | ||
Organism | Escherichia coli O157:H7 strain Vac_07.1 |
Toxin (Protein)
Gene name | symE | Uniprot ID | Q8FA88 |
Locus tag | JKN65_RS23970 | Protein ID | WP_000132630.1 |
Coordinates | 4751875..4752216 (+) | Length | 114 a.a. |
Antitoxin (RNA)
Gene name | symR | ||
Locus tag | - | ||
Coordinates | 4751804..4751880 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JKN65_RS23960 (4748431) | 4748431..4749900 | + | 1470 | WP_001302468.1 | type I restriction-modification system subunit M | - |
JKN65_RS23965 (4749900) | 4749900..4751654 | + | 1755 | WP_000110082.1 | restriction endonuclease subunit S | - |
- (4751804) | 4751804..4751880 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4751804) | 4751804..4751880 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4751804) | 4751804..4751880 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4751804) | 4751804..4751880 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4751804) | 4751804..4751880 | - | 77 | NuclAT_15 | - | Antitoxin |
- (4751804) | 4751804..4751880 | - | 77 | NuclAT_15 | - | Antitoxin |
- (4751804) | 4751804..4751880 | - | 77 | NuclAT_15 | - | Antitoxin |
- (4751804) | 4751804..4751880 | - | 77 | NuclAT_15 | - | Antitoxin |
JKN65_RS23970 (4751875) | 4751875..4752216 | + | 342 | WP_000132630.1 | endoribonuclease SymE | Toxin |
JKN65_RS23975 (4752263) | 4752263..4753426 | - | 1164 | WP_001304006.1 | DUF1524 domain-containing protein | - |
JKN65_RS23980 (4753474) | 4753474..4754355 | - | 882 | WP_001304007.1 | DUF262 domain-containing protein | - |
JKN65_RS23985 (4754498) | 4754498..4754650 | - | 153 | WP_001418365.1 | hypothetical protein | - |
JKN65_RS23990 (4754793) | 4754793..4756205 | + | 1413 | WP_000199295.1 | PLP-dependent aminotransferase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | espX6 | 4744003..4765212 | 21209 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12294.13 Da Isoelectric Point: 8.4982
>T204923 WP_000132630.1 NZ_CP076241:4751875-4752216 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
Download Length: 342 bp
>T204923 NZ_CP101292:c4716035-4715700 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 77 bp
>AT204923 NZ_CP076241:c4751880-4751804 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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