Detailed information of TA system TA020492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1597431..1598086
• Replicon: chromosome
• Accession: NC_002929
• Organism: Bordetella pertussis Tohama I

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: BP_RS07605
• Protein ID: WP_047122780.1
• Coordinates: 1597431..1597682 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: BP_RS07610
• Protein ID: WP_003809516.1
• Coordinates: 1597685..1598086 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BP_RS07580	1592592..1593722	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
BP_RS07585	1593957..1594538	+	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
BP_RS07590	1594675..1595739	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
BP_RS07595	1595824..1596270	-	447	WP_003819827.1	GFA family protein	-
BP_RS07600	1596495..1597376	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
BP_RS07605	1597431..1597682	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
BP_RS07610	1597685..1598086	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
BP_RS07615	1598106..1598342	+	237	WP_010930404.1	membrane protein	-
BP_RS07620	1598350..1598829	+	480	WP_010930405.1	disulfide bond formation protein B	-
BP_RS07625	1598979..1599494	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
BP_RS07630	1599497..1600687	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
BP_RS07635	1600707..1601744	+	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
BP_RS07640	1601881..1602903	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T20492 WP_047122780.1 NC_002929:1597431-1597682 [Bordetella pertussis Tohama I]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T20492 NC_002929:1597431-1597682 [Bordetella pertussis Tohama I]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT20492 WP_003809516.1 NC_002929:1597685-1598086 [Bordetella pertussis Tohama I]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT20492 NC_002929:1597685-1598086 [Bordetella pertussis Tohama I]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6