Detailed information of TA system TA020490

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2939253..2939866
• Replicon: chromosome
• Accession: NC_002928
• Organism: Bordetella parapertussis 12822

Toxin (Protein)

• Gene name: higB
• Uniprot ID: K0MEM3
• Locus tag: BPP_RS13875
• Protein ID: WP_003811545.1
• Coordinates: 2939253..2939564 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BPP_RS13880
• Protein ID: WP_003811547.1
• Coordinates: 2939567..2939866 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BPP_RS13850	2934405..2934959	-	555	Protein_2741	LamB/YcsF family protein	-
BPP_RS13855	2934956..2936350	-	1395	WP_003811536.1	arylsulfatase	-
BPP_RS13860	2936365..2937327	-	963	WP_041937418.1	tripartite tricarboxylate transporter substrate binding protein	-
BPP_RS13865	2937444..2938397	+	954	WP_041937234.1	LysR family transcriptional regulator	-
BPP_RS13870	2938516..2939139	+	624	WP_003811542.1	glutathione S-transferase family protein	-
BPP_RS13875	2939253..2939564	+	312	WP_003811545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BPP_RS13880	2939567..2939866	+	300	WP_003811547.1	helix-turn-helix domain-containing protein	Antitoxin
BPP_RS13885	2939880..2942472	-	2593	Protein_2748	autotransporter domain-containing protein	-
BPP_RS13890	2942602..2943276	+	675	WP_010928712.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-96)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11810.72 Da
• Isoelectric Point: 8.8245

>T20490 WP_003811545.1 NC_002928:2939253-2939564 [Bordetella parapertussis 12822]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Nucleotide

• Length: 312 bp

>T20490 NC_002928:2939253-2939564 [Bordetella parapertussis 12822]
ATGGAGTTCATCGAAACCCCAATTTTCACGCAATTGATCACCGCGTTGCTGTCGGATGAGGAATATTCCAGGCTGCAACA
GCTGCTGATCGACAACCCCGAAAGGGGCGATCTGCTGCGTGGGGGCGGCGGTATACGAAAGATGCGTTACGGCCGGCAAG
GCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGATTGTCAGATCTACATGCTTGCGGCTTAT
GCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCGAACTGGTCAAGGAACTGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10946.70 Da
• Isoelectric Point: 11.2467

>AT20490 WP_003811547.1 NC_002928:2939567-2939866 [Bordetella parapertussis 12822]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Nucleotide

• Length: 300 bp

>AT20490 NC_002928:2939567-2939866 [Bordetella parapertussis 12822]
ATGAAAAAAGACAACACTGTGTTCAACGACCTGCAAGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACTGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGTACGCTGCAGAACTGGGAGCAAGGTCACCGCAATCCGACGGGCCCTGCCGTGGCG
CTTCTGAAAATCGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Structures

Toxin

• AlphaFold DB: K0MEM3