Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4838542..4838954 Replicon chromosome
Accession NZ_CP076237
Organism Escherichia coli O157:H7 strain 146N4

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag JKN67_RS24440 Protein ID WP_000132630.1
Coordinates 4838613..4838954 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4838542..4838618 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKN67_RS24430 (4835169) 4835169..4836638 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
JKN67_RS24435 (4836638) 4836638..4838392 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- (4838542) 4838542..4838618 - 77 NuclAT_14 - Antitoxin
- (4838542) 4838542..4838618 - 77 NuclAT_14 - Antitoxin
- (4838542) 4838542..4838618 - 77 NuclAT_14 - Antitoxin
- (4838542) 4838542..4838618 - 77 NuclAT_14 - Antitoxin
- (4838542) 4838542..4838618 - 77 NuclAT_15 - Antitoxin
- (4838542) 4838542..4838618 - 77 NuclAT_15 - Antitoxin
- (4838542) 4838542..4838618 - 77 NuclAT_15 - Antitoxin
- (4838542) 4838542..4838618 - 77 NuclAT_15 - Antitoxin
JKN67_RS24440 (4838613) 4838613..4838954 + 342 WP_000132630.1 endoribonuclease SymE Toxin
JKN67_RS24445 (4839001) 4839001..4840164 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
JKN67_RS24450 (4840212) 4840212..4841093 - 882 WP_001304007.1 DUF262 domain-containing protein -
JKN67_RS24455 (4841236) 4841236..4841388 - 153 WP_001418365.1 hypothetical protein -
JKN67_RS24460 (4841531) 4841531..4842943 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4832108..4851974 19866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T204894 WP_000132630.1 NZ_CP076237:4838613-4838954 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T204894 NZ_CP101275:142627-143043 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 77 bp

>AT204894 NZ_CP076237:c4838618-4838542 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References