Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2551178..2551649 | Replicon | chromosome |
| Accession | NZ_CP076235 | ||
| Organism | Escherichia coli O157:H7 strain 9.1_Anguil | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | JKN68_RS12885 | Protein ID | WP_001303511.1 |
| Coordinates | 2551178..2551456 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | JKN68_RS12890 | Protein ID | WP_001302048.1 |
| Coordinates | 2551458..2551649 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JKN68_RS12855 (2546403) | 2546403..2546654 | - | 252 | WP_000005552.1 | excisionase family protein | - |
| JKN68_RS12860 (2546727) | 2546727..2549198 | - | 2472 | WP_000048458.1 | exonuclease | - |
| JKN68_RS12865 (2549291) | 2549291..2549482 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| JKN68_RS12870 (2549479) | 2549479..2549667 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| JKN68_RS12875 (2550236) | 2550236..2550454 | - | 219 | WP_001171930.1 | protein YdfC | - |
| JKN68_RS12880 (2550526) | 2550526..2550825 | - | 300 | WP_001240334.1 | hypothetical protein | - |
| JKN68_RS12885 (2551178) | 2551178..2551456 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JKN68_RS12890 (2551458) | 2551458..2551649 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| JKN68_RS12895 (2551670) | 2551670..2552041 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| JKN68_RS12900 (2552139) | 2552139..2552441 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| JKN68_RS12905 (2552438) | 2552438..2552863 | + | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| JKN68_RS12910 (2552886) | 2552886..2553848 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| JKN68_RS12915 (2553855) | 2553855..2554595 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
| JKN68_RS12920 (2554621) | 2554621..2555390 | + | 770 | Protein_2524 | DUF1627 domain-containing protein | - |
| JKN68_RS12925 (2555406) | 2555406..2555801 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| JKN68_RS12930 (2555858) | 2555858..2556442 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | nleG7' | 2546213..2635368 | 89155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T204845 WP_001303511.1 NZ_CP076235:c2551456-2551178 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T204845 NZ_CP101269:c595387-594923 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT204845 WP_001302048.1 NZ_CP076235:c2551649-2551458 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT204845 NZ_CP101269:c595722-595387 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|