Detailed information of TA system TA020483

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1505616..1506316
• Replicon: chromosome
• Accession: NC_002927
• Organism: Bordetella bronchiseptica RB50

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0H3LPJ8
• Locus tag: AYT36_RS07145
• Protein ID: WP_003809515.1
• Coordinates: 1505616..1505912 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: AYT36_RS07150
• Protein ID: WP_003809516.1
• Coordinates: 1505915..1506316 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYT36_RS07125	1501912..1502454	+	543	WP_010926149.1	molybdenum cofactor biosysynthesis protein	-
AYT36_RS07130	1502630..1503694	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
AYT36_RS07135	1503780..1504226	-	447	WP_003809511.1	GFA family protein	-
AYT36_RS07140	1504452..1505333	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
AYT36_RS07145	1505616..1505912	+	297	WP_003809515.1	type II toxin-antitoxin system MqsR family toxin	Toxin
AYT36_RS07150	1505915..1506316	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
AYT36_RS07155	1506336..1506572	+	237	WP_003809519.1	hypothetical protein	-
AYT36_RS07160	1506580..1507059	+	480	WP_003809523.1	disulfide bond formation protein B	-
AYT36_RS07165	1507207..1507722	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
AYT36_RS07170	1507725..1508915	+	1191	WP_010926150.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
AYT36_RS07175	1508935..1509972	+	1038	WP_003809529.1	threonylcarbamoyl-AMP synthase	-
AYT36_RS07180	1510109..1511131	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10608.50 Da
• Isoelectric Point: 7.9291

>T20483 WP_003809515.1 NC_002927:1505616-1505912 [Bordetella bronchiseptica RB50]
MEKGTPHCKLPALKALVHAGQVRATYSALSGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAV
YLKLTVLDGVLIVSFKEL

Nucleotide

• Length: 297 bp

>T20483 NC_002927:1505616-1505912 [Bordetella bronchiseptica RB50]
ATGGAAAAGGGAACACCGCACTGCAAGCTGCCGGCGCTCAAGGCGCTGGTCCATGCAGGCCAGGTCCGAGCCACGTATTC
CGCCTTGTCCGGCGCGGCGGCGCTGGGGCTGGATTTCAGCGCCATGGTCGAAATCGTGCTTGCACTGACACCGCGGGATT
TCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGGACGTCTATTGCCCAGTGACAGCGATGGGTGCCGTC
TACCTGAAGCTGACGGTCCTCGACGGCGTGCTGATCGTGTCGTTCAAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT20483 WP_003809516.1 NC_002927:1505915-1506316 [Bordetella bronchiseptica RB50]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT20483 NC_002927:1505915-1506316 [Bordetella bronchiseptica RB50]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACCATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCCGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGTTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Toxin

• AlphaFold DB: A0A0H3LPJ8

Antitoxin

• AlphaFold DB: A0A0H3LKS6