Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2720616..2721411 | Replicon | chromosome |
| Accession | NZ_CP076232 | ||
| Organism | Escherichia coli O157:H7 strain 7.1_Anguil | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | B7UP43 |
| Locus tag | XE90_RS12950 | Protein ID | WP_000854914.1 |
| Coordinates | 2721037..2721411 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | XE90_RS12945 | Protein ID | WP_046426301.1 |
| Coordinates | 2720616..2720990 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| XE90_RS12915 (2715971) | 2715971..2716876 | + | 906 | WP_000203541.1 | diguanylate cyclase regulator RdcB family protein | - |
| XE90_RS12920 (2716873) | 2716873..2717943 | + | 1071 | WP_000102669.1 | patatin-like phospholipase family protein | - |
| XE90_RS12925 (2718283) | 2718283..2719101 | + | 819 | WP_001234682.1 | DUF932 domain-containing protein | - |
| XE90_RS12930 (2719192) | 2719192..2719677 | + | 486 | WP_000214398.1 | antirestriction protein | - |
| XE90_RS12935 (2719693) | 2719693..2720169 | + | 477 | WP_001186738.1 | RadC family protein | - |
| XE90_RS12940 (2720232) | 2720232..2720453 | + | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
| XE90_RS12945 (2720616) | 2720616..2720990 | + | 375 | WP_046426301.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| XE90_RS12950 (2721037) | 2721037..2721411 | + | 375 | WP_000854914.1 | TA system toxin CbtA family protein | Toxin |
| XE90_RS12955 (2721408) | 2721408..2721899 | + | 492 | WP_000976853.1 | DUF5983 family protein | - |
| XE90_RS12960 (2721911) | 2721911..2722108 | + | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| XE90_RS12965 (2722193) | 2722193..2723035 | + | 843 | WP_001280481.1 | DUF4942 domain-containing protein | - |
| XE90_RS12975 (2723506) | 2723506..2724444 | + | 939 | WP_000351284.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| XE90_RS12980 (2724499) | 2724499..2725236 | + | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| XE90_RS12985 (2725260) | 2725260..2725814 | + | 555 | WP_001001917.1 | molecular chaperone YcdY | - |
| XE90_RS12990 (2725916) | 2725916..2726407 | + | 492 | WP_001301587.1 | DUF1097 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | csgG / csgF / csgE / csgD / csgB / csgA / csgC | 2719693..2731975 | 12282 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14117.17 Da Isoelectric Point: 7.7761
>T204806 WP_000854914.1 NZ_CP076232:2721037-2721411 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T204806 NZ_CP101257:877723-878130 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13777.58 Da Isoelectric Point: 6.9463
>AT204806 WP_046426301.1 NZ_CP076232:2720616-2720990 [Escherichia coli O157:H7]
VSDKLSGITHRDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDKLSGITHRDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT204806 NZ_CP101257:877476-877742 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|