Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2562485..2562669 Replicon chromosome
Accession NC_002758
Organism Staphylococcus aureus subsp. aureus Mu50

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag SAV_RS13255 Protein ID WP_000482652.1
Coordinates 2562562..2562669 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2562485..2562545 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAV_RS13230 2557940..2558107 - 168 Protein_2487 hypothetical protein -
SAV_RS13240 2558338..2560071 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
SAV_RS13245 2560096..2561859 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2562485..2562545 + 61 - - Antitoxin
SAV_RS13255 2562562..2562669 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
SAV_RS13260 2562803..2563189 - 387 WP_000779360.1 flippase GtxA -
SAV_RS13265 2563457..2564599 + 1143 WP_001176863.1 glycerate kinase -
SAV_RS13270 2564659..2565318 + 660 WP_000831298.1 membrane protein -
SAV_RS13275 2565500..2566711 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
SAV_RS13280 2566834..2567307 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T20480 WP_000482652.1 NC_002758:c2562669-2562562 [Staphylococcus aureus subsp. aureus Mu50]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T20480 NC_002758:c2562669-2562562 [Staphylococcus aureus subsp. aureus Mu50]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT20480 NC_002758:2562485-2562545 [Staphylococcus aureus subsp. aureus Mu50]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References