Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4854322..4854734 Replicon chromosome
Accession NZ_CP076230
Organism Escherichia coli O157:H7 strain Rafaela_II

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag XF37_RS24565 Protein ID WP_000132630.1
Coordinates 4854393..4854734 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4854322..4854398 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XF37_RS24555 (4850949) 4850949..4852418 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
XF37_RS24560 (4852418) 4852418..4854172 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- (4854322) 4854322..4854398 - 77 NuclAT_14 - Antitoxin
- (4854322) 4854322..4854398 - 77 NuclAT_14 - Antitoxin
- (4854322) 4854322..4854398 - 77 NuclAT_14 - Antitoxin
- (4854322) 4854322..4854398 - 77 NuclAT_14 - Antitoxin
- (4854322) 4854322..4854398 - 77 NuclAT_15 - Antitoxin
- (4854322) 4854322..4854398 - 77 NuclAT_15 - Antitoxin
- (4854322) 4854322..4854398 - 77 NuclAT_15 - Antitoxin
- (4854322) 4854322..4854398 - 77 NuclAT_15 - Antitoxin
XF37_RS24565 (4854393) 4854393..4854734 + 342 WP_000132630.1 endoribonuclease SymE Toxin
XF37_RS24570 (4854781) 4854781..4855944 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
XF37_RS24575 (4855992) 4855992..4856873 - 882 WP_001304007.1 DUF262 domain-containing protein -
XF37_RS24580 (4857016) 4857016..4857168 - 153 WP_001418365.1 hypothetical protein -
XF37_RS24585 (4857311) 4857311..4858723 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4846521..4867730 21209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T204790 WP_000132630.1 NZ_CP076230:4854393-4854734 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T204790 NZ_CP101251:1318083-1318481 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 77 bp

>AT204790 NZ_CP076230:c4854398-4854322 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References