Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | symER/SymE(toxin) |
Location | 4854322..4854734 | Replicon | chromosome |
Accession | NZ_CP076230 | ||
Organism | Escherichia coli O157:H7 strain Rafaela_II |
Toxin (Protein)
Gene name | symE | Uniprot ID | Q8FA88 |
Locus tag | XF37_RS24565 | Protein ID | WP_000132630.1 |
Coordinates | 4854393..4854734 (+) | Length | 114 a.a. |
Antitoxin (RNA)
Gene name | symR | ||
Locus tag | - | ||
Coordinates | 4854322..4854398 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
XF37_RS24555 (4850949) | 4850949..4852418 | + | 1470 | WP_001302468.1 | type I restriction-modification system subunit M | - |
XF37_RS24560 (4852418) | 4852418..4854172 | + | 1755 | WP_000110082.1 | restriction endonuclease subunit S | - |
- (4854322) | 4854322..4854398 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4854322) | 4854322..4854398 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4854322) | 4854322..4854398 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4854322) | 4854322..4854398 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4854322) | 4854322..4854398 | - | 77 | NuclAT_15 | - | Antitoxin |
- (4854322) | 4854322..4854398 | - | 77 | NuclAT_15 | - | Antitoxin |
- (4854322) | 4854322..4854398 | - | 77 | NuclAT_15 | - | Antitoxin |
- (4854322) | 4854322..4854398 | - | 77 | NuclAT_15 | - | Antitoxin |
XF37_RS24565 (4854393) | 4854393..4854734 | + | 342 | WP_000132630.1 | endoribonuclease SymE | Toxin |
XF37_RS24570 (4854781) | 4854781..4855944 | - | 1164 | WP_001304006.1 | DUF1524 domain-containing protein | - |
XF37_RS24575 (4855992) | 4855992..4856873 | - | 882 | WP_001304007.1 | DUF262 domain-containing protein | - |
XF37_RS24580 (4857016) | 4857016..4857168 | - | 153 | WP_001418365.1 | hypothetical protein | - |
XF37_RS24585 (4857311) | 4857311..4858723 | + | 1413 | WP_000199295.1 | PLP-dependent aminotransferase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | espX6 | 4846521..4867730 | 21209 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12294.13 Da Isoelectric Point: 8.4982
>T204790 WP_000132630.1 NZ_CP076230:4854393-4854734 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
Download Length: 342 bp
>T204790 NZ_CP101251:1318083-1318481 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA
Antitoxin
Download Length: 77 bp
>AT204790 NZ_CP076230:c4854398-4854322 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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