Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2537020..2537537 | Replicon | chromosome |
| Accession | NC_002758 | ||
| Organism | Staphylococcus aureus subsp. aureus Mu50 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | SAV_RS13100 | Protein ID | WP_000113265.1 |
| Coordinates | 2537020..2537286 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | SAV_RS13105 | Protein ID | WP_000584499.1 |
| Coordinates | 2537286..2537537 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SAV_RS13075 | 2532448..2532984 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| SAV_RS13080 | 2533218..2534042 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| SAV_RS13085 | 2534259..2534441 | - | 183 | WP_000230292.1 | hypothetical protein | - |
| SAV_RS13090 | 2534525..2534992 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| SAV_RS13095 | 2535178..2536725 | - | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| SAV_RS15440 | 2536914..2536985 | - | 72 | Protein_2462 | hypothetical protein | - |
| SAV_RS13100 | 2537020..2537286 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| SAV_RS13105 | 2537286..2537537 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| SAV_RS13110 | 2537702..2537803 | - | 102 | Protein_2465 | hypothetical protein | - |
| SAV_RS13115 | 2537810..2538409 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| SAV_RS13120 | 2538428..2538790 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| SAV_RS13125 | 2539045..2540295 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| SAV_RS13130 | 2540392..2541123 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| SAV_RS13135 | 2541120..2541839 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T20479 WP_000113265.1 NC_002758:c2537286-2537020 [Staphylococcus aureus subsp. aureus Mu50]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T20479 NC_002758:c2537286-2537020 [Staphylococcus aureus subsp. aureus Mu50]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT20479 WP_000584499.1 NC_002758:c2537537-2537286 [Staphylococcus aureus subsp. aureus Mu50]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT20479 NC_002758:c2537537-2537286 [Staphylococcus aureus subsp. aureus Mu50]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|