Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2276152..2276368 Replicon chromosome
Accession NC_002758
Organism Staphylococcus aureus subsp. aureus Mu50

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag SAV_RS11740 Protein ID WP_001802298.1
Coordinates 2276264..2276368 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2276152..2276207 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAV_RS11720 2272358..2273023 - 666 WP_001024095.1 SDR family oxidoreductase -
SAV_RS11725 2273175..2273495 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
SAV_RS11730 2273497..2274474 + 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
SAV_RS11735 2274740..2275831 + 1092 WP_000495669.1 hypothetical protein -
- 2276152..2276207 + 56 - - Antitoxin
SAV_RS11740 2276264..2276368 - 105 WP_001802298.1 hypothetical protein Toxin
SAV_RS15380 2277048..2277206 + 159 WP_001792784.1 hypothetical protein -
SAV_RS11745 2277864..2278721 - 858 WP_000370925.1 Cof-type HAD-IIB family hydrolase -
SAV_RS11750 2278789..2279571 - 783 WP_000908182.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-137)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T20477 WP_001802298.1 NC_002758:c2276368-2276264 [Staphylococcus aureus subsp. aureus Mu50]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T20477 NC_002758:c2276368-2276264 [Staphylococcus aureus subsp. aureus Mu50]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT20477 NC_002758:2276152-2276207 [Staphylococcus aureus subsp. aureus Mu50]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References