Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2459766..2460380 Replicon chromosome
Accession NZ_CP076136
Organism Bradyrhizobium sediminis strain S2-11-4

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag KMZ93_RS11860 Protein ID WP_215606235.1
Coordinates 2459766..2460050 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KMZ93_RS11865 Protein ID WP_215606236.1
Coordinates 2460063..2460380 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ93_RS11835 (KMZ93_11835) 2454793..2456187 + 1395 WP_215606232.1 DegQ family serine endoprotease -
KMZ93_RS11840 (KMZ93_11840) 2456184..2457512 + 1329 WP_215606233.1 replication-associated recombination protein A -
KMZ93_RS11845 (KMZ93_11845) 2457640..2458173 + 534 WP_215606234.1 hypothetical protein -
KMZ93_RS11850 (KMZ93_11850) 2458206..2458625 + 420 WP_249779252.1 integrase core domain-containing protein -
KMZ93_RS11855 (KMZ93_11855) 2458660..2459583 - 924 WP_249779253.1 alpha/beta hydrolase -
KMZ93_RS11860 (KMZ93_11860) 2459766..2460050 + 285 WP_215606235.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KMZ93_RS11865 (KMZ93_11865) 2460063..2460380 + 318 WP_215606236.1 HigA family addiction module antitoxin Antitoxin
KMZ93_RS11870 (KMZ93_11870) 2460377..2461579 + 1203 WP_215606237.1 RluA family pseudouridine synthase -
KMZ93_RS11875 (KMZ93_11875) 2461665..2461946 + 282 WP_249779254.1 hypothetical protein -
KMZ93_RS11880 (KMZ93_11880) 2462235..2463017 + 783 WP_215606239.1 ATP12 family protein -
KMZ93_RS11885 (KMZ93_11885) 2463270..2464100 + 831 WP_215606240.1 outer membrane beta-barrel protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10740.09 Da        Isoelectric Point: 8.5406

>T204697 WP_215606235.1 NZ_CP076136:2459766-2460050 [Bradyrhizobium sediminis]
VIVSYRDKATERFASGRHVREFSGFARQAEMRLDRLETAASLADLAALPGNRLEALKGDRAGQFSIRINDQWRIRFRWPE
GSPGPVDVEIVDYY

Download         Length: 285 bp

>T204697 NZ_CP101222:293409-293582 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11613.34 Da        Isoelectric Point: 10.1924

>AT204697 WP_215606236.1 NZ_CP076136:2460063-2460380 [Bradyrhizobium sediminis]
MPRAAIHPGEHLAEELRELGITAAELSRQIDVPVNRITGIIHGQRGITADTALRLGHWFGTAPQFWMNLQQLYELRLAEN
EIGAEIAALPRRAGRSTPRKLGKTA

Download         Length: 318 bp

>AT204697 NZ_CP101222:293085-293381 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References