Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5078914..5079527 Replicon chromosome
Accession NZ_CP076134
Organism Bradyrhizobium sediminis strain S2-20-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KMZ29_RS24435 Protein ID WP_215621574.1
Coordinates 5078914..5079210 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KMZ29_RS24440 Protein ID WP_215621575.1
Coordinates 5079219..5079527 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ29_RS24425 (KMZ29_24425) 5075022..5078438 - 3417 WP_215621573.1 DEAD/DEAH box helicase family protein -
KMZ29_RS24430 (KMZ29_24430) 5078455..5078781 - 327 WP_215624399.1 transcriptional regulator -
KMZ29_RS24435 (KMZ29_24435) 5078914..5079210 + 297 WP_215621574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KMZ29_RS24440 (KMZ29_24440) 5079219..5079527 + 309 WP_215621575.1 HigA family addiction module antitoxin Antitoxin
KMZ29_RS24445 (KMZ29_24445) 5079589..5080788 - 1200 WP_215621576.1 restriction endonuclease subunit S -
KMZ29_RS24450 (KMZ29_24450) 5080785..5082329 - 1545 WP_215621577.1 class I SAM-dependent DNA methyltransferase -
KMZ29_RS24455 (KMZ29_24455) 5082747..5083859 + 1113 WP_215621578.1 cyclic nucleotide-gated ion channel -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-70)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11918.37 Da        Isoelectric Point: 7.3197

>T204692 WP_215621574.1 NZ_CP076134:5078914-5079210 [Bradyrhizobium sediminis]
MIVSFRDDWFREFFVNDVRSKKIPSDLEDRLFRKIQMIDDATTDRDLRSPPSNHFEKLRGNLEGLHSIRVNKRWRLVFRW
DSSRGEAKDLYLDDHSYD

Download         Length: 297 bp

>T204692 NZ_CP101211:87617-88942 [Escherichia coli]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11614.48 Da        Isoelectric Point: 10.8782

>AT204692 WP_215621575.1 NZ_CP076134:5079219-5079527 [Bradyrhizobium sediminis]
MLMTKRKPATTGEILVEEFMKPIGLTQGALAEAMGVQRKHVNELCNDRRNVTAATALILARVFGNSPDFWLNVQRRTDLW
EAMHSPRERKRIERARPLTDAA

Download         Length: 309 bp

>AT204692 NZ_CP101211:87319-87612 [Escherichia coli]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References