Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2325577..2326154 Replicon chromosome
Accession NZ_CP076134
Organism Bradyrhizobium sediminis strain S2-20-1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag KMZ29_RS11100 Protein ID WP_215623717.1
Coordinates 2325873..2326154 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KMZ29_RS11095 Protein ID WP_215623716.1
Coordinates 2325577..2325861 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ29_RS11075 (KMZ29_11075) 2320655..2321788 + 1134 WP_215623712.1 glycosyltransferase family 2 protein -
KMZ29_RS11080 (KMZ29_11080) 2321796..2323298 + 1503 WP_215623713.1 glycosyltransferase family 39 protein -
KMZ29_RS11085 (KMZ29_11085) 2323501..2324238 + 738 WP_215623714.1 DUF899 family protein -
KMZ29_RS11090 (KMZ29_11090) 2324448..2325566 + 1119 WP_215623715.1 DUF2778 domain-containing protein -
KMZ29_RS11095 (KMZ29_11095) 2325577..2325861 - 285 WP_215623716.1 HigA family addiction module antitoxin Antitoxin
KMZ29_RS11100 (KMZ29_11100) 2325873..2326154 - 282 WP_215623717.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KMZ29_RS11105 (KMZ29_11105) 2326259..2326855 - 597 WP_215623718.1 cysteine hydrolase family protein -
KMZ29_RS11110 (KMZ29_11110) 2326985..2327827 + 843 WP_215623719.1 LysR family transcriptional regulator -
KMZ29_RS11115 (KMZ29_11115) 2327993..2329636 - 1644 WP_215623720.1 chaperonin GroEL -
KMZ29_RS11120 (KMZ29_11120) 2329778..2330095 - 318 WP_215606075.1 co-chaperone GroES -
KMZ29_RS11125 (KMZ29_11125) 2330475..2330762 + 288 WP_215623721.1 usg protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10714.32 Da        Isoelectric Point: 9.3512

>T204689 WP_215623717.1 NZ_CP076134:c2326154-2325873 [Bradyrhizobium sediminis]
MIRSFADKATELLFRGGPCPARWRSIEAVALRKLDMVDAATRLDDLLSPPGNRLEALKGDRRGQHSIRINRQWRICFRWT
PDGPEAIEIVDYH

Download         Length: 282 bp

>T204689 NZ_CP101210:4552060-4552470 [Escherichia coli]
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACAGGCCTGATGACACGTAA
TAACTACAGAATGGTAAATAACATTACCCTGGGTAGCATCCGGGGGCGAAACGATGAAACTTTCCCTGACGCTGGAAGCC
GACAGCATTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10691.37 Da        Isoelectric Point: 10.3620

>AT204689 WP_215623716.1 NZ_CP076134:c2325861-2325577 [Bradyrhizobium sediminis]
MARLRTHPGEVLKEEYLVPLGLSARVLAKELDIPANRLTEIMRGARDVSADTAIRLGRYFRTDPRFWLNLQAAYDLSKAE
NTHSYKKIVPRPAA

Download         Length: 285 bp

>AT204689 NZ_CP101210:4551601-4551969 [Escherichia coli]
GTGTCAGACACACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGACATCAGAGGCCGGT
TCAGCGATGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References