204687

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3832718..3833990 Replicon chromosome
Accession NZ_CP076128
Organism Flammeovirga kamogawensis strain YS10

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag KM029_RS15530 Protein ID WP_245006605.1
Coordinates 3833040..3833990 (+) Length 317 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag KM029_RS15525 Protein ID WP_144074111.1
Coordinates 3832718..3833053 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM029_RS15500 (KM029_15500) 3828246..3829031 + 786 WP_144074106.1 hypothetical protein -
KM029_RS15505 (KM029_15505) 3829795..3830211 - 417 WP_144074107.1 hypothetical protein -
KM029_RS15510 (KM029_15510) 3830224..3830967 - 744 WP_144074108.1 hypothetical protein -
KM029_RS15515 (KM029_15515) 3831643..3831897 + 255 WP_262712704.1 hypothetical protein -
KM029_RS15520 (KM029_15520) 3832501..3832731 + 231 WP_144074110.1 type II toxin-antitoxin system Y4mF family antitoxin -
KM029_RS15525 (KM029_15525) 3832718..3833053 + 336 WP_144074111.1 HipA N-terminal domain-containing protein Antitoxin
KM029_RS15530 (KM029_15530) 3833040..3833990 + 951 WP_245006605.1 HipA domain-containing protein Toxin
KM029_RS15535 (KM029_15535) 3834337..3834828 - 492 WP_144074112.1 hypothetical protein -
KM029_RS15540 (KM029_15540) 3834815..3835141 - 327 WP_144074113.1 hypothetical protein -
KM029_RS15545 (KM029_15545) 3835332..3835520 - 189 WP_144074114.1 hypothetical protein -
KM029_RS15550 (KM029_15550) 3835531..3835971 - 441 WP_144074115.1 hypothetical protein -
KM029_RS15555 (KM029_15555) 3836335..3837036 - 702 WP_144074116.1 response regulator transcription factor -
KM029_RS15560 (KM029_15560) 3837040..3838098 - 1059 WP_158631076.1 histidine kinase -
KM029_RS15565 (KM029_15565) 3838322..3838702 + 381 WP_144074118.1 MotA/TolQ/ExbB proton channel family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-284)

Antitoxin

HipA, N-terminal subdomain 1

(5-102)


Sequences

Toxin        


Download         Length: 317 a.a.        Molecular weight: 36000.58 Da        Isoelectric Point: 8.1003

>T204687 WP_245006605.1 NZ_CP076128:3833040-3833990 [Flammeovirga kamogawensis]
MMMSKCLYCYQPIEERGDYHEKCSKSFFGTSLPPQLEYTFSEMEMLAKEAVERSITITGVQAKLSMGVVKTTANTSDQRL
TVLDALGGSYIFKPPSKQFEGMSEVEHVTMKIAQAYGLSTVPCSLIRLASGELSYITRRVDRTKKGEKTHMIDMFQITEA
FDKYRSSMEKIGKAINQYSNQPLLDNIYFFELSVFSFLTGNNDMHLKNFSLINSANGWVLAPAYDLLNVNVLLPEDEEEL
ALTLKGKRKKLKRDHFESFGIELGLNQRQINGVFKRMIKNFSKALEALDQSFLSESLKEKYKEVLGIKYKQLGLLD

Download         Length: 951 bp

>T204687 NZ_CP101210:3978979-3979356 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12947.84 Da        Isoelectric Point: 4.4188

>AT204687 WP_144074111.1 NZ_CP076128:3832718-3833053 [Flammeovirga kamogawensis]
MRKGKVYYQEQLAGILVETDEGEYTFQYVDDYIQNFPKQFITFSMPVCSKVYKENRLFPFFEGLIPEGWLLDIASKNWKI
NTNDRMGLLLTCCKNCIGAVSILPEKENDDE

Download         Length: 336 bp

>AT204687 NZ_CP101210:3978558-3978932 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References