Detailed information of TA system TA020468

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1934328..1934508
• Replicon: chromosome
• Accession: NC_002758
• Organism: Staphylococcus aureus subsp. aureus Mu50

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: SAV_RS15670
• Protein ID: WP_001801861.1
• Coordinates: 1934328..1934423 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1934451..1934508 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAV_RS09650	1929491..1930141	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
SAV_RS09655	1930222..1931217	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
SAV_RS09660	1931292..1931918	+	627	WP_000669024.1	hypothetical protein	-
SAV_RS09665	1931959..1932300	+	342	WP_000627540.1	DUF3969 family protein	-
SAV_RS09670	1932401..1932973	+	573	WP_000414216.1	hypothetical protein	-
SAV_RS15275	1933171..1934183	-	1013	Protein_1838	IS3 family transposase	-
SAV_RS15670	1934328..1934423	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1934451..1934508	-	58	-	-	Antitoxin
SAV_RS09690	1934546..1934647	+	102	WP_001792025.1	hypothetical protein	-
SAV_RS15675	1934625..1934786	-	162	Protein_1841	transposase	-
SAV_RS09695	1934777..1935271	-	495	Protein_1842	transposase	-
SAV_RS09700	1935723..1936952	-	1230	WP_000072626.1	restriction endonuclease subunit S	-
SAV_RS09705	1936945..1938501	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
SAV_RS09710	1938665..1938799	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1910310..1961342	51032

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T20468 WP_001801861.1 NC_002758:1934328-1934423 [Staphylococcus aureus subsp. aureus Mu50]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T20468 NC_002758:1934328-1934423 [Staphylococcus aureus subsp. aureus Mu50]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT20468 NC_002758:c1934508-1934451 [Staphylococcus aureus subsp. aureus Mu50]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin