Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3508233..3508829 Replicon chromosome
Accession NZ_CP076114
Organism Pseudomonas seleniipraecipitans strain D1-6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D16iCDA_RS16205 Protein ID WP_083328633.1
Coordinates 3508233..3508511 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D16iCDA_RS16210 Protein ID WP_070881183.1
Coordinates 3508524..3508829 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D16iCDA_RS16190 (D16iCDA_16185) 3503835..3506882 - 3048 WP_164090921.1 sensor histidine kinase -
D16iCDA_RS16195 (D16iCDA_16190) 3507062..3507394 + 333 WP_164090922.1 hypothetical protein -
D16iCDA_RS16200 (D16iCDA_16195) 3507428..3508177 + 750 Protein_3159 tyrosine-type recombinase/integrase -
D16iCDA_RS16205 (D16iCDA_16200) 3508233..3508511 + 279 WP_083328633.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D16iCDA_RS16210 (D16iCDA_16205) 3508524..3508829 + 306 WP_070881183.1 HigA family addiction module antitoxin Antitoxin
D16iCDA_RS16220 (D16iCDA_16215) 3509118..3509684 - 567 WP_083328634.1 cupin domain-containing protein -
D16iCDA_RS16225 (D16iCDA_16220) 3509822..3510922 - 1101 WP_070881184.1 redox-regulated ATPase YchF -
D16iCDA_RS16230 (D16iCDA_16225) 3510958..3511548 - 591 WP_070881185.1 aminoacyl-tRNA hydrolase -
D16iCDA_RS16235 (D16iCDA_16230) 3511600..3512223 - 624 WP_070881186.1 50S ribosomal protein L25/general stress protein Ctc -
D16iCDA_RS16240 (D16iCDA_16235) 3512334..3513275 - 942 WP_070881187.1 ribose-phosphate pyrophosphokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10636.11 Da        Isoelectric Point: 8.5301

>T204640 WP_083328633.1 NZ_CP076114:3508233-3508511 [Pseudomonas seleniipraecipitans]
VILSFKCPETRALFETGDSRRWKNILNVATRKLTMLHAATELRDLRSPPGNRLEALQGNRMGQYSIRINDQFRVCFEWSD
AGPTNVEIVDYH

Download         Length: 279 bp

>T204640 NZ_CP101197:759243-759539 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11320.85 Da        Isoelectric Point: 4.6606

>AT204640 WP_070881183.1 NZ_CP076114:3508524-3508829 [Pseudomonas seleniipraecipitans]
MAINGMRPIHPGEILREEFLEPLDISPAALARALHVSAPTVNEIVRERRGVTADMAIRLGRYFDTSAQFWMNLQTDYSLA
TTFAANGEEIEHEIEPLRAQA

Download         Length: 306 bp

>AT204640 NZ_CP101197:759541-759936 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References