Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2409674..2410197 | Replicon | chromosome |
| Accession | NZ_CP076105 | ||
| Organism | Staphylococcus aureus subsp. aureus RN4220 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | X5DYX7 |
| Locus tag | KMZ21_RS11880 | Protein ID | WP_000074048.1 |
| Coordinates | 2409674..2409940 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | W8TQT5 |
| Locus tag | KMZ21_RS11885 | Protein ID | WP_000587616.1 |
| Coordinates | 2409940..2410197 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KMZ21_RS11860 (KMZ21_11860) | 2404981..2406168 | - | 1188 | WP_000026194.1 | MFS transporter | - |
| KMZ21_RS11865 (KMZ21_11865) | 2406564..2407340 | - | 777 | WP_000072147.1 | iron export ABC transporter permease subunit FetB | - |
| KMZ21_RS11870 (KMZ21_11870) | 2407333..2407995 | - | 663 | WP_000923520.1 | ATP-binding cassette domain-containing protein | - |
| KMZ21_RS11875 (KMZ21_11875) | 2408243..2409319 | - | 1077 | WP_001076671.1 | M42 family metallopeptidase | - |
| KMZ21_RS11880 (KMZ21_11880) | 2409674..2409940 | - | 267 | WP_000074048.1 | Txe/YoeB family addiction module toxin | Toxin |
| KMZ21_RS11885 (KMZ21_11885) | 2409940..2410197 | - | 258 | WP_000587616.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KMZ21_RS11890 (KMZ21_11890) | 2410556..2411011 | + | 456 | WP_000732082.1 | DUF1307 domain-containing protein | - |
| KMZ21_RS11895 (KMZ21_11895) | 2411179..2412756 | - | 1578 | WP_000143503.1 | FMN-binding glutamate synthase family protein | - |
| KMZ21_RS11900 (KMZ21_11900) | 2412951..2413700 | + | 750 | WP_000072443.1 | CPBP family lipoprotein N-acylation protein LnsB | - |
| KMZ21_RS11905 (KMZ21_11905) | 2413924..2415117 | - | 1194 | WP_000675401.1 | MFS transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10648.23 Da Isoelectric Point: 10.1384
>T204636 WP_000074048.1 NZ_CP076105:c2409940-2409674 [Staphylococcus aureus subsp. aureus RN4220]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD
Download Length: 267 bp
>T204636 NZ_CP101197:215985-216092 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9774.73 Da Isoelectric Point: 4.1353
>AT204636 WP_000587616.1 NZ_CP076105:c2410197-2409940 [Staphylococcus aureus subsp. aureus RN4220]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL
Download Length: 258 bp
>AT204636 NZ_CP101197:c215927-215873 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|