Detailed information of TA system TA204634

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2378173..2378357
• Replicon: chromosome
• Accession: NZ_CP076105
• Organism: Staphylococcus aureus subsp. aureus RN4220

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: KMZ21_RS11740
• Protein ID: WP_000482650.1
• Coordinates: 2378250..2378357 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2378173..2378233 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KMZ21_RS11725 (KMZ21_11725)	2373703..2373870	-	168	WP_001790576.1	hypothetical protein	-
KMZ21_RS11730 (KMZ21_11730)	2374101..2375834	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
KMZ21_RS11735 (KMZ21_11735)	2375859..2377622	-	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
-	2378173..2378233	+	61	-	-	Antitoxin
KMZ21_RS11740 (KMZ21_11740)	2378250..2378357	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
KMZ21_RS11745 (KMZ21_11745)	2378491..2378877	-	387	WP_000779358.1	flippase GtxA	-
KMZ21_RS11750 (KMZ21_11750)	2379145..2380287	+	1143	WP_001176863.1	glycerate kinase	-
KMZ21_RS11755 (KMZ21_11755)	2380347..2381006	+	660	WP_000831298.1	membrane protein	-
KMZ21_RS11760 (KMZ21_11760)	2381188..2382399	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KMZ21_RS11765 (KMZ21_11765)	2382522..2382995	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T204634 WP_000482650.1 NZ_CP076105:c2378357-2378250 [Staphylococcus aureus subsp. aureus RN4220]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T204634 NZ_CP101185:4075118-4075408 [Paenarthrobacter ureafaciens]
GTGAGCAATTCCAGCTTGGAGGGCGAGCCGTGGAACATTCAGGTCACAAGTCCGGCACTGAAAACATTTCATCGGCTTCC
CGAAAAGGCCGCCTCCGCCATAGTGGAGTTCATAACCGGGGCCCTGGCAGGCAACCCACACCGCCTCAGCAAACCCCTGA
CCAATGAACTTCTTGGCATGCGCACCGCCCGCCGAGGTGATTACCGCGTGTTGTTCACCCTCGACATCGAGGACCACGTG
CTCTATGTCCATCGAATTCAGCACCGCGCAGATGTCTACAAACCTCGCTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT204634 NZ_CP076105:2378173-2378233 [Staphylococcus aureus subsp. aureus RN4220]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin