Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2352821..2353338 Replicon chromosome
Accession NZ_CP076105
Organism Staphylococcus aureus subsp. aureus RN4220

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag KMZ21_RS11605 Protein ID WP_000113262.1
Coordinates 2352821..2353087 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KMZ21_RS11610 Protein ID WP_000584499.1
Coordinates 2353087..2353338 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ21_RS11575 (KMZ21_11575) 2348247..2348783 - 537 WP_000169315.1 GNAT family N-acetyltransferase -
KMZ21_RS11580 (KMZ21_11580) 2349016..2349840 - 825 WP_000572040.1 formate/nitrite transporter family protein -
KMZ21_RS11585 (KMZ21_11585) 2350057..2350239 - 183 WP_000230294.1 hypothetical protein -
KMZ21_RS11590 (KMZ21_11590) 2350323..2350790 - 468 WP_000153344.1 SRPBCC domain-containing protein -
KMZ21_RS11595 (KMZ21_11595) 2350976..2352526 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KMZ21_RS11600 (KMZ21_11600) 2352715..2352786 - 72 Protein_2237 hypothetical protein -
KMZ21_RS11605 (KMZ21_11605) 2352821..2353087 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
KMZ21_RS11610 (KMZ21_11610) 2353087..2353338 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KMZ21_RS11615 (KMZ21_11615) 2353503..2353604 - 102 WP_001791744.1 hypothetical protein -
KMZ21_RS11620 (KMZ21_11620) 2353611..2354210 - 600 WP_000162813.1 DsbA family protein -
KMZ21_RS11625 (KMZ21_11625) 2354229..2354591 - 363 WP_000819843.1 DUF4467 domain-containing protein -
KMZ21_RS11630 (KMZ21_11630) 2354846..2356096 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
KMZ21_RS11635 (KMZ21_11635) 2356193..2356924 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KMZ21_RS11640 (KMZ21_11640) 2356921..2357640 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T204633 WP_000113262.1 NZ_CP076105:c2353087-2352821 [Staphylococcus aureus subsp. aureus RN4220]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T204633 NZ_CP101180:4068767-4069057 [Paenarthrobacter ureafaciens]
GTGAGCAATTCCAGCTTGGAGGGCGAGCCGTGGAACATTCAGGTCACAAGTCCGGCACTGAAAACATTTCATCGGCTTCC
CGAAAAGGCCGCCTCCGCCATAGTGGAGTTCATAACCGGGGCCCTGGCAGGCAACCCACACCGCCTCAGCAAACCCCTGA
CCAATGAACTTCTTGGCATGCGCACCGCCCGCCGAGGTGATTACCGCGTGTTGTTCACCCTCGACATCGAGGACCACGTG
CTCTATGTCCATCGAATTCAGCACCGCGCAGATGTCTACAAACCTCGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT204633 WP_000584499.1 NZ_CP076105:c2353338-2353087 [Staphylococcus aureus subsp. aureus RN4220]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT204633 NZ_CP101180:4068495-4068770 [Paenarthrobacter ureafaciens]
ATGAAGACGGTTCCCCTCAGCGAGGCCAAGGACAAACTCTCGGCCTTGGTCGAAGAAGCAGACACCACACACGAAATCAT
TCAGATCACTCGCCACGGACACCCGTCGGCCGTCCTCATGTCTGCGGATGACCTGGAATCACTTCAGGAAACCATCCACT
GGCTGTCCCAACCGGGCCTACGTGAGGATCTTGCACAGGCTCGCCGCGATATCGCAGAGGGCAACACAGTAAGCGGCGAT
GACCTGCGCCGTGAATTCGGACTGCCTCCCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References