Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 2701763..2702262 | Replicon | chromosome |
| Accession | NZ_CP076104 | ||
| Organism | Nocardioides sp. LMS-CY | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | - |
| Locus tag | KM427_RS13050 | Protein ID | WP_215524138.1 |
| Coordinates | 2701763..2702020 (-) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | - |
| Locus tag | KM427_RS13055 | Protein ID | WP_215524139.1 |
| Coordinates | 2702017..2702262 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KM427_RS13020 (KM427_13020) | 2697949..2698497 | + | 549 | WP_215527462.1 | GNAT family protein | - |
| KM427_RS13025 (KM427_13025) | 2698519..2699082 | - | 564 | WP_183594744.1 | dihydrofolate reductase family protein | - |
| KM427_RS13030 (KM427_13030) | 2699147..2699716 | - | 570 | WP_215527463.1 | dienelactone hydrolase family protein | - |
| KM427_RS13035 (KM427_13035) | 2699784..2700377 | + | 594 | WP_252274451.1 | winged helix-turn-helix domain-containing protein | - |
| KM427_RS13040 (KM427_13040) | 2700311..2700844 | - | 534 | WP_215524136.1 | sigma-70 family RNA polymerase sigma factor | - |
| KM427_RS13045 (KM427_13045) | 2700846..2701676 | - | 831 | WP_215524137.1 | hypothetical protein | - |
| KM427_RS13050 (KM427_13050) | 2701763..2702020 | - | 258 | WP_215524138.1 | Txe/YoeB family addiction module toxin | Toxin |
| KM427_RS13055 (KM427_13055) | 2702017..2702262 | - | 246 | WP_215524139.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| KM427_RS13060 (KM427_13060) | 2702579..2703052 | + | 474 | WP_215524140.1 | hypothetical protein | - |
| KM427_RS13065 (KM427_13065) | 2703099..2703494 | + | 396 | WP_215524141.1 | MmcQ/YjbR family DNA-binding protein | - |
| KM427_RS13070 (KM427_13070) | 2703507..2705867 | - | 2361 | WP_215524142.1 | excinuclease ABC subunit UvrA | - |
| KM427_RS13075 (KM427_13075) | 2705967..2706194 | - | 228 | WP_221200110.1 | hypothetical protein | - |
| KM427_RS13080 (KM427_13080) | 2706206..2706619 | - | 414 | WP_183594737.1 | VOC family protein | - |
| KM427_RS13085 (KM427_13085) | 2706630..2707088 | - | 459 | WP_215524143.1 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10124.53 Da Isoelectric Point: 7.4014
>T204624 WP_215524138.1 NZ_CP076104:c2702020-2701763 [Nocardioides sp. LMS-CY]
VRLVFTPNGWDDYQHWLQADRQILKRINRLIDDALRDPTDGIGKPEPLRHMFAGAWSRRITDEHRLVYLVDGEDLVVLQA
RFHYK
VRLVFTPNGWDDYQHWLQADRQILKRINRLIDDALRDPTDGIGKPEPLRHMFAGAWSRRITDEHRLVYLVDGEDLVVLQA
RFHYK
Download Length: 258 bp
>T204624 NZ_CP101174:3696501-3696992 [Xanthomonas campestris pv. campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCTTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCTTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9083.30 Da Isoelectric Point: 5.7152
>AT204624 WP_215524139.1 NZ_CP076104:c2702262-2702017 [Nocardioides sp. LMS-CY]
MPVTASEARKQLFPLIEKVNNDRIAVEITSRRGNAVLISAEEFAALEETAYLLRVPANAKRLLESLQQARSGDRHEHELA
E
MPVTASEARKQLFPLIEKVNNDRIAVEITSRRGNAVLISAEEFAALEETAYLLRVPANAKRLLESLQQARSGDRHEHELA
E
Download Length: 246 bp
>AT204624 NZ_CP101174:3696214-3696504 [Xanthomonas campestris pv. campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|