Detailed information of TA system TA204619

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1059157..1059677
• Replicon: chromosome
• Accession: NZ_CP076082
• Organism: Limosilactobacillus fermentum strain 9-4

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KBK05_RS05620
• Protein ID: WP_088460800.1
• Coordinates: 1059157..1059420 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: KBK05_RS05625
• Protein ID: WP_215509001.1
• Coordinates: 1059417..1059677 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KBK05_RS05605	1054773..1055813	-	1041	WP_215508998.1	Gfo/Idh/MocA family oxidoreductase	-
KBK05_RS05610	1056478..1057392	+	915	WP_215508999.1	hypothetical protein	-
KBK05_RS05615	1057866..1058987	+	1122	WP_215509000.1	PTS sugar transporter subunit IIC	-
KBK05_RS05620	1059157..1059420	-	264	WP_088460800.1	Txe/YoeB family addiction module toxin	Toxin
KBK05_RS05625	1059417..1059677	-	261	WP_215509001.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KBK05_RS05630	1059839..1060504	-	666	Protein_1098	family 1 glycosylhydrolase	-
KBK05_RS05635	1060756..1061415	-	660	WP_215509003.1	3,4-dihydroxy-2-butanone-4-phosphate synthase	-
KBK05_RS05640	1061894..1062298	-	405	WP_252265311.1	hypothetical protein	-
KBK05_RS05645	1062303..1062659	-	357	WP_215509005.1	MmcQ/YjbR family DNA-binding protein	-
KBK05_RS05650	1062661..1063308	-	648	WP_252265313.1	sel1 repeat family protein	-
KBK05_RS05655	1063376..1064595	+	1220	Protein_1103	IS256 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (25-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-55)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10311.02 Da
• Isoelectric Point: 10.3042

>T204619 WP_088460800.1 NZ_CP076082:c1059420-1059157 [Limosilactobacillus fermentum]
MSYAIKLKRSANKDLKKIKGSYLEKSFLQIIEQLRKDPLAPNQGFEKLVPPIKGFYSRRINIQYRLVYKVDQDTQTVIIY
SAWSHYE

Nucleotide

• Length: 264 bp

>T204619 NZ_CP101170:c4512130-4511996 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10058.40 Da
• Isoelectric Point: 4.5866

>AT204619 WP_215509001.1 NZ_CP076082:c1059677-1059417 [Limosilactobacillus fermentum]
MDKIVTPTQARKDLFKIIKRINENNEPVVIKPTRADEKSVVVIGEDDWKAIQETLFLVNHGVDKQIKERERENEPLDDFD
DVWGQL

Nucleotide

• Length: 261 bp

>AT204619 NZ_CP101170:c4512359-4512207 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA