Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 185970..186703 Replicon chromosome
Accession NZ_CP076060
Organism Cupriavidus sp. EM10

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag KLP38_RS00850 Protein ID WP_215529057.1
Coordinates 185970..186266 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID -
Locus tag KLP38_RS00855 Protein ID WP_215530230.1
Coordinates 186302..186703 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KLP38_RS00830 (KLP38_00830) 181865..183145 - 1281 WP_215529054.1 muropeptide transporter -
KLP38_RS00835 (KLP38_00835) 183238..184197 + 960 WP_225934326.1 M48 family metallopeptidase -
KLP38_RS00840 (KLP38_00840) 184306..184770 + 465 WP_215529055.1 excinuclease ATPase -
KLP38_RS00845 (KLP38_00845) 184858..185805 - 948 WP_215529056.1 N-acetyl-gamma-glutamyl-phosphate reductase -
KLP38_RS00850 (KLP38_00850) 185970..186266 + 297 WP_215529057.1 type II toxin-antitoxin system MqsR family toxin Toxin
KLP38_RS00855 (KLP38_00855) 186302..186703 + 402 WP_215530230.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
KLP38_RS00860 (KLP38_00860) 186731..187507 - 777 WP_215529058.1 exodeoxyribonuclease III -
KLP38_RS00865 (KLP38_00865) 187538..188215 + 678 WP_215529059.1 orotate phosphoribosyltransferase -
KLP38_RS00870 (KLP38_00870) 188273..189601 + 1329 WP_215529060.1 patatin-like phospholipase family protein -
KLP38_RS00875 (KLP38_00875) 189622..190431 - 810 WP_215529061.1 polyphosphate kinase 2 family protein -
KLP38_RS00880 (KLP38_00880) 190518..191384 - 867 WP_215529062.1 diaminopimelate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-96)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11137.77 Da        Isoelectric Point: 9.9232

>T204615 WP_215529057.1 NZ_CP076060:185970-186266 [Cupriavidus sp. EM10]
MEKSTAHYRLAQVRALIAERRVVFTASAAQGHQAMSMSRAEALAVVEKLGSADFYKSMTTYRDHRVWQDVYHPSTPYGSL
YVKLTVQDDLLVVSFKVR

Download         Length: 297 bp

>T204615 NZ_CP101169:416673-416825 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14769.83 Da        Isoelectric Point: 5.2952

>AT204615 WP_215530230.1 NZ_CP076060:186302-186703 [Cupriavidus sp. EM10]
MRCPECGGADLVKGRRDLPYTYRGESTVVEDVEGEWCPLCGEGVLSREAHERLDDVALAFNKQVNASLVDPTFIVSVRKK
LRLDQKEAGEIFGGGVNAFSRYETGRTKPPLSLVQLLKLLDRHPDLLDELRAG

Download         Length: 402 bp

>AT204615 NZ_CP101169:416905-417039 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References