Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 409654..410162 Replicon plasmid unnamed2
Accession NZ_CP076047
Organism Rhodococcus sp. USK10

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6P1IBG8
Locus tag I1A62_RS02600 Protein ID WP_072948949.1
Coordinates 409902..410162 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q0RYC5
Locus tag I1A62_RS02595 Protein ID WP_005569061.1
Coordinates 409654..409905 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I1A62_RS02580 (I1A62_02585) 405034..406182 - 1149 WP_257890378.1 zinc-ribbon domain-containing protein -
I1A62_RS02585 (I1A62_02590) 407086..408792 - 1707 WP_219453894.1 DEAD/DEAH box helicase family protein -
I1A62_RS02590 (I1A62_02595) 409115..409528 + 414 WP_174705570.1 hypothetical protein -
I1A62_RS02595 (I1A62_02600) 409654..409905 + 252 WP_005569061.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
I1A62_RS02600 (I1A62_02605) 409902..410162 + 261 WP_072948949.1 Txe/YoeB family addiction module toxin Toxin
I1A62_RS02605 (I1A62_02610) 410328..410588 + 261 Protein_423 alpha/beta hydrolase -
I1A62_RS02610 (I1A62_02615) 410987..411994 - 1008 WP_219453895.1 acyl-CoA dehydrogenase family protein -
I1A62_RS02615 (I1A62_02620) 412242..413183 - 942 WP_257890379.1 Rep protein -
I1A62_RS02620 (I1A62_02625) 413923..414243 - 321 WP_219453899.1 hypothetical protein -
I1A62_RS02625 (I1A62_02630) 414240..414734 - 495 WP_219453901.1 hypothetical protein -
I1A62_RS02630 (I1A62_02635) 414731..415042 - 312 WP_219453902.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..1355759 1355759


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10412.81 Da        Isoelectric Point: 8.8670

>T204610 WP_072948949.1 NZ_CP076047:409902-410162 [Rhodococcus sp. USK10]
MKLVWDESAWEDYVWWQAQDRKIVKRINTLLKDVERNGNDGIGKPEPLKHGFQGYWSRRITDEHRLVYKIVDDQIRIAAC
RYHYGH

Download         Length: 261 bp

>T204610 NZ_CP101137:504929-505192 [Streptomyces sp. M92]
ATGTCCATCACCGCCAGCGAAGCCCGTCAGAACCTGTTCCCGCTGATAGAGCAGGTCAACGAGGACCATGCCCCGGTGCA
CATCACCTCCCGCAAGGGGAACGCCGTGCTGATGTCCGAGGAGGACTTCACGGCGTGGACGGAGACCGTGCACCTGCTGC
GGTCGCCGAGGAACGCCCGCCGTCTGCTCGACTCGATCGCGGAGGCCGAGGCCGGCGAGGCGCGGCACCGCGAGCTGATC
GACCCGGACGCGGAGCGGGCGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9358.50 Da        Isoelectric Point: 4.5216

>AT204610 WP_005569061.1 NZ_CP076047:409654-409905 [Rhodococcus sp. USK10]
MRTMTYSESRARYAEVLNAVVDDREEIVITRAGHEPVVMVSLDDYESLKETAYLLRSPENARRLLASIDRLESGGGTVRD
LAE

Download         Length: 252 bp

>AT204610 NZ_CP101137:505189-505443 [Streptomyces sp. M92]
GTGAGGATCGCTTTCACGTCGCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGATGACCAGACGGAT
CAACAGACTGCTCGCCGACACCGCCCGCGACCCGTTCAAGGGCATCGGCAAGCCGGAGCCGCTGAAGGGCGACCTGTCCG
GCTACTGGTCACGGCGCATCGACGACACGCACCGTCTGGTGTACAAGCCGGGCGACGACGAACTGATCGTCGTCCAGGCG
CGGTACCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1IBG8

Antitoxin

Source ID Structure
AlphaFold DB Q0RYC5

References