Detailed information of TA system TA204577

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1963160..1963683
• Replicon: chromosome
• Accession: NZ_CP076029
• Organism: Staphylococcus sp. MZ9

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KI244_RS09850
• Protein ID: WP_045177693.1
• Coordinates: 1963160..1963426 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: KI244_RS09855
• Protein ID: WP_000587618.1
• Coordinates: 1963426..1963683 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI244_RS09830 (KI244_09830)	1958466..1959653	-	1188	WP_045177690.1	MFS transporter	-
KI244_RS09835 (KI244_09835)	1960049..1960825	-	777	WP_000072151.1	iron export ABC transporter permease subunit FetB	-
KI244_RS09840 (KI244_09840)	1960818..1961480	-	663	WP_045177691.1	ATP-binding cassette domain-containing protein	-
KI244_RS09845 (KI244_09845)	1961728..1962804	-	1077	WP_001076673.1	M42 family metallopeptidase	-
KI244_RS09850 (KI244_09850)	1963160..1963426	-	267	WP_045177693.1	Txe/YoeB family addiction module toxin	Toxin
KI244_RS09855 (KI244_09855)	1963426..1963683	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KI244_RS09860 (KI244_09860)	1964043..1964498	+	456	WP_000732090.1	YehR family lipoprotein	-
KI244_RS09865 (KI244_09865)	1964666..1966243	-	1578	WP_000143503.1	FMN-binding glutamate synthase family protein	-
KI244_RS09870 (KI244_09870)	1966438..1967187	+	750	WP_000072443.1	CPBP family lipoprotein N-acylation protein LnsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (26-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10684.35 Da
• Isoelectric Point: 10.1384

>T204577 WP_045177693.1 NZ_CP076029:c1963426-1963160 [Staphylococcus sp. MZ9]
MSNYTVKIKNSAKLDLKKIKHPYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T204577 NZ_CP101115:487285-487680 [Acinetobacter sp. Z1]
ATGTCCATGGCTAGTCGTCTTTTCGAGCTGCAATACAGCCGTTTTTCGATTGTATTGCAGCTTTTTGTATTTCTTACTAT
TTCAATTCTAAGCTATCAATTACTCCATATGATGTTGTGGTTGTTAAGTCTCGGAATCATGGCTTTCGCATGGTTTAAGC
TATCCAAGCAGCCATCCATCATTCGTTTTGAATATTTAGATCAACACATCTGGTCGTTTGAATTTTCAGATAAGAATTTA
GCAATTCAACGTTTGAAGATTACTAAAATAATTGACCATAAAGCTTATGTTTCAATTCATATTGCTGACTCGAGTTGCAA
AACTTACATCATTTGGTGGGATCAATTGTCATATTTGCAATGGAAAAATCTAAAATTACTGGCAAAACTGATTTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT204577 WP_000587618.1 NZ_CP076029:c1963683-1963426 [Staphylococcus sp. MZ9]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT204577 NZ_CP101115:487041-487298 [Acinetobacter sp. Z1]
ATGTCTGATGAAATGACTCTTGAAGAACGTAAAGTAATTTATCGCGCACGTCGTGGTTTAAAAGAAATTGATGTGTATTT
TGATCCTTATGTGAAGAATCACTATTTAACCGCTGATCAAGCAGAAAAAGCTTTGTTTGCTGAATTGGTTGAGCAAGAAG
ATCCTGATTTGCTTGATTGGTTTATGGAAGTCGGTGAACCACCGCGAAATGAATTAAAAGATTTTATTTTAAAACTAAAA
CATTATGTCCATGGCTAG

Structures

Antitoxin

• AlphaFold DB: T1YBB2