Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1906619..1907136 Replicon chromosome
Accession NZ_CP076029
Organism Staphylococcus sp. MZ9

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag KI244_RS09575 Protein ID WP_000113262.1
Coordinates 1906619..1906885 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KI244_RS09580 Protein ID WP_000584499.1
Coordinates 1906885..1907136 (-) Length 84 a.a.

Genomic Context

KI244_RS09600KI244_RS09550KI244_RS09555KI244_RS09560KI244_RS09565KI244_RS09570KI244_RS14070KI244_RS09575KI244_RS09580KI244_RS09585KI244_RS09590KI244_RS09595KI244_RS09605KI244_RS09610
Location: 1908644..1909894 (1251 bp)
Type: Others
Protein ID: WP_001012241.1
Location: 1902046..1902582 (537 bp)
Type: Others
Protein ID: WP_000169317.1
Location: 1902815..1903639 (825 bp)
Type: Others
Protein ID: WP_045177662.1
Location: 1903856..1904038 (183 bp)
Type: Others
Protein ID: WP_000230294.1
Location: 1904122..1904589 (468 bp)
Type: Others
Protein ID: WP_000153346.1
Location: 1904775..1906325 (1551 bp)
Type: Others
Protein ID: WP_045177665.1
Location: 1906513..1906584 (72 bp)
Type: Others
Protein ID: WP_223200558.1
Location: 1906619..1906885 (267 bp)
Type: Toxin
Protein ID: WP_000113262.1
Location: 1906885..1907136 (252 bp)
Type: Antitoxin
Protein ID: WP_000584499.1
Location: 1907301..1907402 (102 bp)
Type: Others
Protein ID: WP_001791744.1
Location: 1907409..1908008 (600 bp)
Type: Others
Protein ID: WP_000162812.1
Location: 1908027..1908389 (363 bp)
Type: Others
Protein ID: WP_000819843.1
Location: 1909991..1910722 (732 bp)
Type: Others
Protein ID: WP_000615461.1
Location: 1910719..1911438 (720 bp)
Type: Others
Protein ID: WP_000479576.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KI244_RS09550 (KI244_09550)1902046..1902582-537WP_000169317.1GNAT family N-acetyltransferase-
KI244_RS09555 (KI244_09555)1902815..1903639-825WP_045177662.1formate/nitrite transporter family protein-
KI244_RS09560 (KI244_09560)1903856..1904038-183WP_000230294.1hypothetical protein-
KI244_RS09565 (KI244_09565)1904122..1904589-468WP_000153346.1SRPBCC domain-containing protein-
KI244_RS09570 (KI244_09570)1904775..1906325-1551WP_045177665.1zinc ABC transporter substrate-binding lipoprotein AdcA-
KI244_RS140701906513..1906584-72WP_223200558.1hypothetical protein-
KI244_RS09575 (KI244_09575)1906619..1906885-267WP_000113262.1Txe/YoeB family addiction module toxinToxin
KI244_RS09580 (KI244_09580)1906885..1907136-252WP_000584499.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
KI244_RS09585 (KI244_09585)1907301..1907402-102WP_001791744.1hypothetical protein-
KI244_RS09590 (KI244_09590)1907409..1908008-600WP_000162812.1DsbA family protein-
KI244_RS09595 (KI244_09595)1908027..1908389-363WP_000819843.1DUF4467 domain-containing protein-
KI244_RS09600 (KI244_09600)1908644..1909894+1251WP_001012241.1FemA/FemB family glycyltransferase FmhA-
KI244_RS09605 (KI244_09605)1909991..1910722-732WP_000615461.1amino acid ABC transporter ATP-binding protein-
KI244_RS09610 (KI244_09610)1910719..1911438-720WP_000479576.1amino acid ABC transporter permease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T204574 WP_000113262.1 NZ_CP076029:c1906885-1906619 [Staphylococcus sp. MZ9]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T204574 NZ_CP101114:807289-807603 [Bartonella harrusi]
ATGATACATAAAAGAACGAATGAAGGTGATTTTGTGATTGAATCTTTTGCGGATAAGCGGTGTAAAGATCTTTTAGAAGG
GAATCCGCCCAGAGGCTTTCCTCCAACTCTAGTGCGTATAGCCCAAAGAAAATTATTTATGCTTGATAAGGCAGTTGATC
TCAAGGATTTGCGCAGTCCTCCGGGAAATCGTCTAGAGGCATTGAAAGGAGAGCGTAAAGGTCAATATTCTATTCGTATT
AATGATCAGTTTCGTATTTGTTTTGAATGGCGTTCTAATGGCGCCTATGAAGTTGAAATTGTAGATTATCATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT204574 WP_000584499.1 NZ_CP076029:c1907136-1906885 [Staphylococcus sp. MZ9]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT204574 NZ_CP101114:807620-807916 [Bartonella harrusi]
ATGAAAAATTATATAGCAATACACCCCGGAGAAATTTTACGAGAAGAATATTTAAAAGAATATGCTCTTTCTGCTTATGC
TCTTGCAAAAGCATTGAATGTTCCACGCACGAGGATAGAACGGATTGTTGCTGAAAACAGTCCAGTCACTCCCGATACAG
CACTAAGATTAGCTTATTTTTTTGATACCACTGCTGAATTTTGGCTTAACATGCAAGCTGCTTACGACGTTAGTATATTA
CAAACTGAAAAAGCAGATGAATTTGCTAAAATCAATAAATTTGAATGTAGGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6L8G
PDB6L8F
PDB7CUA
PDB6L8E

Antitoxin

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Source
ID
Structure
PDB6L8G
PDB6L8F
PDB7BWF
PDB6L8E
AlphaFold DBT1YB60

References