Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 347589..348003 Replicon chromosome
Accession NZ_CP076029
Organism Staphylococcus sp. MZ9

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KI244_RS01790 Protein ID WP_025174939.1
Coordinates 347589..347840 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KI244_RS01795 Protein ID WP_000028424.1
Coordinates 347830..348003 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI244_RS01730 (KI244_01730) 342819..343247 + 429 WP_000934385.1 single-stranded DNA-binding protein -
KI244_RS01735 (KI244_01735) 343261..343935 + 675 WP_001124439.1 putative HNHc nuclease -
KI244_RS01740 (KI244_01740) 343932..344081 + 150 WP_001081076.1 hypothetical protein -
KI244_RS01745 (KI244_01745) 344074..344355 - 282 WP_000414755.1 hypothetical protein -
KI244_RS01750 (KI244_01750) 344421..345191 + 771 WP_000190253.1 conserved phage C-terminal domain-containing protein -
KI244_RS01755 (KI244_01755) 345201..345980 + 780 WP_000803062.1 ATP-binding protein -
KI244_RS01760 (KI244_01760) 345974..346132 + 159 WP_000256590.1 hypothetical protein -
KI244_RS01765 (KI244_01765) 346145..346366 + 222 WP_001123685.1 DUF3269 family protein -
KI244_RS01770 (KI244_01770) 346377..346781 + 405 WP_000049810.1 DUF1064 domain-containing protein -
KI244_RS01775 (KI244_01775) 346786..346971 + 186 WP_049317452.1 DUF3113 family protein -
KI244_RS01780 (KI244_01780) 346972..347328 + 357 WP_000029369.1 SA1788 family PVL leukocidin-associated protein -
KI244_RS01785 (KI244_01785) 347332..347574 + 243 WP_000131381.1 phi PVL orf 51-like protein -
KI244_RS01790 (KI244_01790) 347589..347840 + 252 WP_025174939.1 DUF1024 family protein Toxin
KI244_RS01795 (KI244_01795) 347830..348003 + 174 WP_000028424.1 hypothetical protein Antitoxin
KI244_RS01800 (KI244_01800) 348004..348285 + 282 WP_000454994.1 hypothetical protein -
KI244_RS01805 (KI244_01805) 348286..348447 + 162 WP_000889683.1 hypothetical protein -
KI244_RS01810 (KI244_01810) 348462..348995 + 534 WP_025920701.1 dUTP diphosphatase -
KI244_RS01815 (KI244_01815) 349032..349238 + 207 WP_000195827.1 DUF1381 domain-containing protein -
KI244_RS01820 (KI244_01820) 349235..349429 + 195 Protein_347 hypothetical protein -
KI244_RS01825 (KI244_01825) 349426..349629 + 204 WP_001072795.1 hypothetical protein -
KI244_RS01830 (KI244_01830) 349622..349858 + 237 WP_000608278.1 hypothetical protein -
KI244_RS01835 (KI244_01835) 349851..350024 + 174 WP_000595257.1 transcriptional activator RinB -
KI244_RS01840 (KI244_01840) 350025..350171 + 147 WP_000990005.1 hypothetical protein -
KI244_RS01845 (KI244_01845) 350195..350617 + 423 WP_000162701.1 RinA family phage transcriptional activator -
KI244_RS01850 (KI244_01850) 350805..351299 + 495 WP_001038244.1 terminase small subunit -
KI244_RS01855 (KI244_01855) 351302..352597 + 1296 WP_117172029.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - eta 334046..377602 43556


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9361.22 Da        Isoelectric Point: 3.8464

>T204568 WP_025174939.1 NZ_CP076029:347589-347840 [Staphylococcus sp. MZ9]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T204568 NZ_CP100765:c4269076-4268654 [Serratia nematodiphila]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTAACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGCTGGCGGATCGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGACTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAAGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAATGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAGGAATCCTGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT204568 WP_000028424.1 NZ_CP076029:347830-348003 [Staphylococcus sp. MZ9]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT204568 NZ_CP100765:c4269323-4269057 [Serratia nematodiphila]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATTTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References